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			<p class="Type-of-Article">Research Article</p>
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			<p class="title- ParaOverride-1">&nbsp;</p>
			<p class="title- ParaOverride-1">Haematobiochemical Profile in Chronic Acetamiprid Exposure in Sprague Dawley Rats</p>
		</div>
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			<p class="Authors ParaOverride-1">&nbsp;</p>
			<p class="Authors ParaOverride-1"><span class="CharOverride-1">Samiran Mondal</span><span class="CharOverride-2">1</span><span class="CharOverride-1">*, Sunit Kumar Mukhopadhayay</span><span class="CharOverride-2">1</span><span class="CharOverride-1">, Sanjit Kumar</span><span class="CharOverride-2">1</span><span class="CharOverride-1">, Partha Sarathi Mandal</span><span class="CharOverride-2">1</span><span class="CharOverride-1">, Saktipada Pradhan</span><span class="CharOverride-2">1</span><span class="CharOverride-1">, Sreerupa Biswas</span><span class="CharOverride-2">2</span><span class="CharOverride-1">, Kamal Purohit</span><span class="CharOverride-2">3</span></p>
		</div>
		<div class="Basic-Text-Frame">
			<p class="Affiliations ParaOverride-1"><span class="CharOverride-3">1</span>Department of Veterinary Pathology, WBUAFS, Kolkata 37; <span class="CharOverride-3">2</span>Associate Operations Specialist at Quintiles; <span class="CharOverride-3">3</span>Department of Veterinary Pathology, RAJUVAS, India.</p>
		</div>
		<div>
			<p class="Abstract ParaOverride-1">&nbsp;</p>
			<p class="Abstract ParaOverride-1"><span class="CharOverride-4">Abstract</span> | A chronic study was conducted on Sprague Dawley (SD) rats for 13 weeks using 48 rats in four groups each having 12 animals. Group I was control. Group II, III and IV were treatment groups receiving acetamiprid in distilled water in the amount of 5mg/kg, 20mg/kg and 40mg/kg, respectively. Body weight gain and feed consumption was decreased. There was lymphocytopenea in acetamiprid treated animal. Liver and kidney marker enzymes and analyte were altered compared to control after 13 weeks of acetamiprid exposure. This study concluded that acetamiprid, used even in this dose range could cause a significant effect on hematobiochemical profile.</p>
		  <p class="Abstract ParaOverride-1">&nbsp;</p>
			<p class="Abstract ParaOverride-1"><span class="CharOverride-4">Keywords</span> | Acetamiprid, Chronic study, Lymphocytopanea, SD rat</p>
		  <p class="Abstract ParaOverride-1">&nbsp;</p>
		</div>
		<div class="Basic-Text-Frame">
			<p class="Editor----Citation"><span class="CharOverride-4">Editor</span> | Kuldeep Dhama, Indian Veterinary Research Institute, Uttar Pradesh, India.</p>
			<p class="Editor----Citation"><span class="CharOverride-4">Received</span> | May 23, 2015; <span class="CharOverride-4">Revised</span> | June 02, 2015; <span class="CharOverride-4">Accepted</span> | June 03, 2015; <span class="CharOverride-4">Published</span> | June 12, 2015&#9;&#9;</p>
			<p class="Editor----Citation"><span class="CharOverride-4">*Correspondence</span> | Samiran Mondal, Department of Veterinary Pathology, WBUAFS, Kolkata, India; <span class="CharOverride-4">Email: </span>vetsamiran@gmail.com</p>
			<p class="Editor----Citation"><span class="CharOverride-4">Citation</span> | Mondal S, Mukhopadhayay SK, Kumar S, Mandal PS, Pradhan S, Biswas S, Purohit K (2015). Haematobiochemical profile in chronic acetamiprid exposure in Sprague Dawley rats. Adv. Anim. Vet. Sci. 3(7): 384-394.  </p>
			<p class="Editor----Citation"><span class="CharOverride-4">DOI</span> | <a href="http://dx.doi.org/10.14737/journal.aavs/2015/3.7.384.394"><span class="Hyperlink">http://dx.doi.org/10.14737/journal.aavs/2015/3.7.384.394</span></a></p>
			<p class="Editor----Citation"><span class="Editor---Citation CharOverride-4">ISSN (Online)</span> | 2307-8316; <span class="Editor---Citation CharOverride-4">ISSN (Print)</span> | 2309-3331</p>
			<p class="Editor----Citation"><span class="CharOverride-4">Copyright</span> © 2015 Mondal et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</p>
		</div>
		<div class="Basic-Text-Frame">
			<p class="Heading-1--Introduction----">&nbsp;</p>
		  <p class="Heading-1--Introduction----">INTRODUCTION </p>
			<p class="Caps-on-First-Para ParaOverride-1">&nbsp;</p>
			<p class="Caps-on-First-Para ParaOverride-1"><span class="_idGenDropcap-1">S</span><span>ince </span>insecticides are often required to decrease insect pest population and associated crop damage and losses, knowledge of the non-target effects of each choice is essential for selection of the most appropriate insecticide for the situation (<a href="#Wolfenbarger-LL--Naranjo-SE--Lundgren-JG--Bitzer-RJ--Watrud-LS--2008"><span class="Hyperlink">Wolfenbarger et al., 2008</span></a>). Higher uses of acetamiprid to manage the insects by the farmers are causing residue related toxicity to consumer through food chain. Information regarding selectivity of insecticide for judicial use might be generated only through properly designed laboratory and field studies (<a href="#Mondal-S--Ghosh-2010"><span class="Hyperlink">Mondal et al., 2010</span></a>).</p>
		  <p class="Caps-on-First-Para ParaOverride-1">&nbsp;</p>
			<p class="Body-Text ParaOverride-1">The persistence and extreme stability of pesticides in the environment are the ultimate source of contamination at the dietary level. As insecticides are used as crop protectants, they are likely to cause indirect exposure in human, domestic as well as wild animal and poultry through feed contaminants, soil and ground water as through ecotoxicant.  Even sublethal dose of acetamiprid caused alteration in the electrolyte and micro-mineral balance in mammals (<a href="#Mondal-S--Ghosh-2012"><span class="Hyperlink">Mondal et al., 2012</span></a>). Indiscriminate introduction of acetamiprid into food chain through agroindustry may affect the haematobiochemical system of animal and human causing high susceptibility to various diseases and secondary infection. In the present study focus has been made to see the changes in haematobiochemical parameters after multiple exposure to acetamiprid for 13 weeks.</p>
		  <p class="Body-Text ParaOverride-1">&nbsp;</p>
			<p class="Heading-1--Introduction----">MATERIALS AND METHODS</p>
		  <p class="Heading-1--Introduction----">&nbsp;</p>
			<p class="Heading-2--History-in-MM-">Study Design </p>
			<p class="Body-Text ParaOverride-1">For chronic toxicity study, 48 Sprague Dawley rats were used. Before starting of this experiment, the protocol was approved by IAEC, WBUAFS. For experiment purpose total 48 animals were used in four dose group having 12 animals each.<span class="CharOverride-4"> </span>Group I was control group received only distilled water. Goup II, group III and group IV was treated with acetamiprid at dose rate of 5, 20 and 40 mg/kg body weight respectively. </p>
		  <p class="Body-Text ParaOverride-1">&nbsp;</p>
			<p class="Heading-2--History-in-MM-">Husbandry</p>
			<p class="Body-Text ParaOverride-1">Ani&#173;mals were allowed to acclimatize for a period of 7 days prior to experiment and provided standard feed (Nu&#173;tri Lab, rodent feed, Vetcare Pvt. Ltd, Bangalore) and allowed water, both ad libitum (RO &amp; UV treated). Three animals per cage were accommodated in polycarbonate cages during the experimental period. Husk was used as bedding material. Husk was strained and sterilized by auto&#173;claving in transparent polythene bag using sterol strip as an indicator of successful sterilization. Changing frequency of bedding material was twice a week.</p>
		  <p class="Body-Text ParaOverride-1">&nbsp;</p>
			<p class="Heading-2--History-in-MM-">Chemicals and Formulation</p>
			<p class="Body-Text ParaOverride-1">Acetamiprid (CAS No-135410-20-7) was procured from Sigma Aldrich, USA. Acetamiprid was formu&#173;lated using distilled water as a vehicle. Acetamiprid solution was administered directly in stomach by oral gavages at dose of 5 mg/kg body weight to group II, 20 mg/kg body weight to group III and 40 mg/kg body weight to rats of group IV respectively with dose volume of 10 ml/kg for 13 weeks daily. The control group (Group I) received distilled water. Body weight of rats was recorded weekly for proper administra&#173;tion of acetamiprid solution. </p>
		  <p class="Body-Text ParaOverride-1">&nbsp;</p>
			<p class="Heading-2--History-in-MM-">Clinical Observations</p>
			<p class="Body-Text ParaOverride-1">Animals were observed twice daily by cage side observation. For clinical observation a time frame of 6:30 to 7:30 both AM and PM was kept. Detailed observations were noted weekly.</p>
		  <p class="Body-Text ParaOverride-1">&nbsp;</p>
			<p class="Heading-2--History-in-MM-">Body Weights</p>
			<p class="Body-Text ParaOverride-1"><span class="CharOverride-4"> </span>Body weights of all animals were taken before start of experiment and then after weekly during the whole study period on electronic balance (model no-T30, E.G. Kantawalla Pvt. Ltd, Pune, India).  </p>
		  <p class="Body-Text ParaOverride-1">&nbsp;</p>
			<p class="Heading-2--History-in-MM-">Feed Consumption</p>
			<p class="Body-Text">Food consumption was monitored continuously throughout study. For this, measured amount of feed was provided to the animal and left over feed was measured on next morning before giving any feed to animal. Feed consumption of each group was calculated based on consumption per cage.</p>
		  <p class="Body-Text">&nbsp;</p>
			<p class="Heading-2--History-in-MM-">Haematology</p>
			<p class="Body-Text ParaOverride-1">Collection of blood was done on 1st, 2nd, 5th, 9th and 13th week under light isoflurane anaesthesia into heparinised ependorf by retro-orbital puncture method. Animals were given sufficient time to get under anaesthesia to avoid hypoxic condition or handling related stress. Following blood parameters were analysed manually. Haematological studies were carried out on the day of collection of blood. Haemoglobin (Hb) content of blood was estimated by Sahli’s hemoglobinometer (<a href="#Coles-EM--986-"><span class="Hyperlink">Coles, 1986</span></a>). Haematocrit value (HCt) was estimated by microhematocrit method (<a href="#Coles-EM--986-"><span class="Hyperlink">Coles, 1986</span></a>). Total erythrocyte count (TEC), Platelets (PLT) and Total leukocyte count (TLC) were estimated as per the method described by <a href="#Jain-NC--1986"><span class="Hyperlink">Jain (1986)</span></a> by using Gower’s solution (s d fine- chem. limited, Mumbai - 400030), platelet diluting fluid (Nice chemicals, Kolkata) and W.B.C. diluting fluid (Merck Limited, Mumbai-400018) respectively. Differential leukocyte count was determined as per the method described by <a href="#Jain-NC--1986"><span class="Hyperlink">Jain (1986)</span></a> with slight modification. </p>
		  <p class="Body-Text ParaOverride-1">&nbsp;</p>
			<p class="Heading-2--History-in-MM-">Blood Chemistry</p>
			<p class="Body-Text ParaOverride-1">Following blood collection it was spun at 1640g at 4°C for 5 minutes. Plasma was collected and stored at -20°C for biochemical analysis. Aspertate amino transferase, Alanine aminotransferase, Alkaline phosphatase, glucose, total protein, albumin, globulin, albumin/globulin ratio, total bilirubin, urea, creatinine, phosphorus, calcium, sodium, potasium and chlorine levels in plasma were estimated as per manufactue’s instruction. </p>
		  <p class="Body-Text ParaOverride-1">&nbsp;</p>
			<p class="Heading-2--History-in-MM-">Statistical Analysis</p>
			<p class="Body-Text ParaOverride-1">Data were analysed using graphpad prism software version 4. Two way ANOVA followed by dunnett’s multiple comparison test were employed to see the difference if any.</p>
			<p class="Heading-1--Introduction----">&nbsp;</p>
			<p class="Heading-1--Introduction----">RESULTS</p>
		  <p class="Heading-1--Introduction----">&nbsp;</p>
			<p class="Heading-2--History-in-MM-">Clinical Observation</p>
			<p class="Body-Text">There were no severe toxic signs in any of groups compare to rats of control group. Chromodacryorrhoea was observed in group IV rat. Treated animals were reluctant to move as compare to control rats. Group IV rats were depressed, showed signs of mouth smacking and mild salivation.   </p>
		  <p class="Body-Text">&nbsp;</p>
			<p class="Heading-2--History-in-MM-">Body Weight</p>
			<p class="Body-Text ParaOverride-1"> In the present study a dose dependent significant (P≤0.05) decreases in body weights were found in all the treatment groups on 8 week onwards. Group IV (40 mg/kg group) showed significant reduction in body weight gain on 8<span class="CharOverride-8">th</span> week onwards; in group III significant reduction in body weight was observed on 10 week onwards as compared to rats of control group. However in the whole experiment, group II did not show any alteration in body weight gain significantly as compared to control animal (<a href="#Figure-1-"><span class="Hyperlink">Figure 1</span></a>).</p>
		  <p class="Body-Text ParaOverride-1">&nbsp;</p>
			
            <div class="pt" > <a href="http://nexusacademicpublishers.com/uploads/figures/20150612212049.png" target="new"><img class="img_display" src="http://nexusacademicpublishers.com/uploads/figures/20150612212049.png" width="80" height="80"></a>
            
           <p class="Figure--and-Table-Heading ParaOverride-1"><span class="CharOverride-4"><a id="Figure-1-"></a>Figure 1: </span><a href="http://nexusacademicpublishers.com/uploads/figures/20150612212049.png">Stair graph showing effect of acetamiprid on weekly body weight in experimental group</a></p>
       </div>

			
		  <p class="Figure--and-Table-Heading ParaOverride-1"><span class="CharOverride-5">*p≤0.05; **p≤0.01; ***p≤0.001</span></p>
			<p class="Heading-2--History-in-MM-">&nbsp;</p>
		  <p class="Heading-2--History-in-MM-">Feed Consumption</p>
			<p class="Body-Text ParaOverride-1">Feed consumption was measured on daily basis per cage. Data were depicted in form of cumulative consumption in a week per animal in <a href="#Figure-2-"><span class="Hyperlink">Figure 2</span></a>. There was significant difference in feed consumption of acetamiprid treated animal (mid dose and high dose group) of this experiment. In 2<span class="CharOverride-8">nd</span> week per animal consumption in group IV was significantly (p≤0.01) reduced compared to control animal although other groups under this experiment did not show any significant difference as compared to rats of control group. The same trend was noticed in 3<span class="CharOverride-8">rd</span> week. In 4<span class="CharOverride-8">th</span> week, rats of group III and group IV consumed significantly (p≤0.01) less amount of feed as compared with the rats of control group. And the same trends were observed in 5<span class="CharOverride-8">th</span> week of acetamiprid exposure. In the 6<span class="CharOverride-8">th</span> week of experiment, there was dose dependent significant (p≤0.05) decreased in feed consumption compared with control animal. In 7<span class="CharOverride-8">th</span> &amp; 8th week, only group IV animal which received 40 mg/kg body weight showed significant reduction (p≤0.05) in feed consumption. </p>
		  <p class="Body-Text ParaOverride-1">&nbsp;</p>
			
            <div class="pt" > <a href="http://nexusacademicpublishers.com/uploads/figures/20150612214649.png" target="new"><img class="img_display" src="http://nexusacademicpublishers.com/uploads/figures/20150612214649.png" width="80" height="80"></a>
            
         <p class="Figure--and-Table-Heading ParaOverride-1"><span class="CharOverride-4"><a id="Figure-2-"></a>Figure 2: </span><a href="http://nexusacademicpublishers.com/uploads/figures/20150612214649.png">Line graph showing effect of acetamiprid on weekly feed consumption in experimental group</a></p>
       </div>
       
			
		  <p class="Figure--and-Table-Heading ParaOverride-1"><span class="CharOverride-5">*p≤0.05; **p≤0.01</span></p>
			<p class="Heading-2--History-in-MM-">&nbsp;</p>
		  <p class="Heading-2--History-in-MM-">Haematology </p>
			<p class="Body-Text ParaOverride-1">The effect of chronic acetamiprid toxicity on mean values of total erythrocyte counts (X10<span class="CharOverride-8">6</span>/µl), hemoglobin (gm/dl), haematocrit value (%), mean corpuscular volume (fl), mean corpuscular hemoglobin (pg), mean corpuscular hemoglobin concentration (gm/dl), Platelets (X10<span class="CharOverride-8">3</span>/µl), and total leukocyte count (X10<span class="CharOverride-8">3</span>/µl) along with relative counts of neutrophil, lymphocyte, eosinophil, monocyte and basophil for each experimental groups in different week are given in <a href="#Table-1-"><span class="Hyperlink">Table 1</span></a>. The administration of acetamiprid orally for 13 week did not cause any significant (P≤0.05) alteration in the levels of TEC, TLC, Hgb, HCT, PLT, MCV, MCH and MCHC. Significant (P≤0.001) increase in the mean values of percent neutrophil was found in the rats of group IV in 5<span class="CharOverride-8">th</span>, 9<span class="CharOverride-8">th</span> and 13<span class="CharOverride-8">th</span> week as compared to control group. The augmented level of percent neutrophil count was also observed in group II at 13<span class="CharOverride-8">th</span> week (P≤0.01). However there was significant decrease (P≤0.01) in percent lymphocyte count in the rats of group IV in 5<span class="CharOverride-8">th</span>, 9<span class="CharOverride-8">th</span> and 13<span class="CharOverride-8">th</span> weeks of acetamiprid exposure as compared to rats to control group. There was also reduction in percent lymphocyte count in group III at 13<span class="CharOverride-8">th</span> weeks of exposure as compared to group I. However there was no significant differences on percent eosiniphil, monocyte and basophil in acetamiprid administered rats as compared to control group.</p>
		  <p class="Body-Text ParaOverride-1">&nbsp;</p>
			<p class="Heading-2--History-in-MM-">Blood Chemistry  </p>
		  <p class="Heading-2--History-in-MM-">&nbsp;</p>
			<p class="Heading-3">Aspartate Amino Transferase</p>
			<p class="Body-Text ParaOverride-1">There was no significant alteration in any group in AST level up to 2<span class="CharOverride-8">nd</span> week of acetamiprid exposure. In the 5<span class="CharOverride-8">th</span> week there was significant increase in AST level in 20mg/kg and 40 mg/kg group as compare to control group. After 9<span class="CharOverride-8">th</span> week of exposure of acetamiprid to rat caused significant augmentation in the level AST in a dose dependent manner. Similarly after 13<span class="CharOverride-8">th</span> week of exposure to acetamiprid in rat caused significant increase in plasma level of AST compared to control rat in dose dependent manner (<a href="#Table-2-"><span class="Hyperlink">Table 2</span></a>).  </p>
			<p class="Heading-3">&nbsp;</p>
		  <p class="Heading-3">Alanine Amino Transferase</p>
			<p class="Body-Text ParaOverride-1">Effect of daily oral administration of acetamiprid on plasma alanine amino transferase of rats of experimental groups were presented in <a href="#Table-3-"><span class="Hyperlink">Table 3</span></a>. There was dose dependent significant (P≤0.05) increase in plasma level of ALT activity in the acetamiprid treated rats compared to rats of control group from 5<span class="CharOverride-8">th</span> week of exposure and this trend existed upto 13<span class="CharOverride-8">th</span> week of exposure of acetamiprid.</p>
		  <p class="Body-Text ParaOverride-1">&nbsp;</p>
			<p class="Heading-3">Alkaline Phosphatase</p>
			<p class="Body-Text ParaOverride-1">Augmented level of ALP activity was observed (P≤0.05) at 5<span class="CharOverride-8">th</span> week of acetamiprid exposure as compare to group I. There was dose dependent significant (P≤0.05) increase in plasma level of ALP activity acetamiprid treated rats compared to rats of control group (<a href="#Table-4-"><span class="Hyperlink">Table</span><span class="Hyperlink"> 4</span></a>).</p>
		  <p class="Body-Text ParaOverride-1">&nbsp;</p>
			<p class="Heading-3">Glucose</p>
			<p class="Body-Text ParaOverride-1">The effect of the acetamiprid on plasma glucose level in Sprague Dawley rats during chronic toxicity study is given in <a href="#Table-5-"><span class="Hyperlink">Table 5</span></a>. There was significant (P≤0.05) decrease in the plasma glucose level of rats of group IV (acetamiprid 40 mg/kg) compared to rats of the control group at 5<span class="CharOverride-8">th</span> week of exposure whereas at the same time no significant difference in plasma concentration of glucose was found among the rats of group I, II and III. At 9<span class="CharOverride-8">th</span> week, though there were no significant differences in the rats of group II &amp; III compared to rats of control group, but a significant reduction was found in rats of group IV in comparison to vehicle group. There were also a significant reduction of plasma glucose in rats of group III and group IV compared to vehicle one.</p>
		  <p class="Body-Text ParaOverride-1">&nbsp;</p>
			
		  <p class="Figure--and-Table-Heading ParaOverride-1"><span class="CharOverride-4"><a id="Table-1-"></a>Table 1:</span> Effect of Acetamiprid on Hematology after 13 weeks of exposure in SD Rats</p>
			<table width="657" height="1108" class="Table-Style-1" id="table-1">
				<colgroup>
					<col />
					<col />
					<col />
					<col />
					<col />
					<col />
					<col />
					<col />
					<col />
					<col />
					<col />
					<col />
					<col />
					<col />
					<col />
				</colgroup>
				<tbody>
					<tr class="_idGenTableRowColumn-1">
						<td width="23">
							<p class="Basic-Paragraph"><span class="CharOverride-11">&#160;</span></p>
						</td>
						<td width="28">
							<p class="Basic-Paragraph"><span class="CharOverride-11">±</span></p>
						</td>
						<td width="40">
							<p class="Basic-Paragraph"><span class="CharOverride-11">&#160;</span></p>
						</td>
						<td colspan="5">
							<p class="Basic-Paragraph"><span class="CharOverride-11">Differential count %</span></p>
						</td>
						<td width="37">
							<p class="Basic-Paragraph"><span class="CharOverride-11">**</span></p>
						</td>
						<td width="43">
							<p class="Basic-Paragraph"><span class="CharOverride-11">***</span></p>
						</td>
						<td width="37">
							<p class="Basic-Paragraph"><span class="CharOverride-11">&#160;</span></p>
						</td>
						<td width="53">
							<p class="Basic-Paragraph"><span class="CharOverride-11">&#160;</span></p>
						</td>
						<td width="40">
							<p class="Basic-Paragraph"><span class="CharOverride-11">&#160;</span></p>
						</td>
						<td width="40">
							<p class="Basic-Paragraph"><span class="CharOverride-11">&#160;</span></p>
						</td>
						<td width="47">
							<p class="Basic-Paragraph"><span class="CharOverride-11">&#160;</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-2">
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">Wk</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">Gro</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">up</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">WBC (10</span><span class="CharOverride-13">3</span><span class="CharOverride-12">/µl)</span></p>
						</td>
						<td width="52">
							<p class="Basic-Paragraph"><span class="CharOverride-12">Neutr</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">ophil</span></p>
						</td>
						<td width="52">
							<p class="Basic-Paragraph"><span class="CharOverride-12">Lymph</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">ocyte</span></p>
						</td>
						<td width="37">
							<p class="Basic-Paragraph"><span class="CharOverride-12">Mono</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">cyte</span></p>
						</td>
						<td width="37">
							<p class="Basic-Paragraph"><span class="CharOverride-12">Eosi</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">nophil</span></p>
						</td>
						<td width="37">
							<p class="Basic-Paragraph"><span class="CharOverride-12">Baso</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">phil</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">RBC (10</span><span class="CharOverride-13">6</span><span class="CharOverride-12">/µl)</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">HGB (gm/dl)</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">HCT (%)</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">PLT (</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">10</span><span class="CharOverride-13">3</span><span class="CharOverride-12">/ µl)</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">MCV (fL)</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">MCH (pg)</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">MCHC (gm/dl)</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-1">
						<td rowspan="4">
							<p class="Basic-Paragraph"><span class="CharOverride-12">1</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">Veh</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">icle</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">6.22±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.42</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">10.5±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">1.25</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">86.5±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">1.23</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">2.67±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.43</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.59±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.28</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0±0</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">6.71±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.52</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">14.57</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±1.27</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">35.22</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±2.69</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">524±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">71.96</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">52.5±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.39</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">21.7</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±0.4</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">41.26</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±0.75</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-2">
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">Gr II</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">6.64±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.72</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">11.5±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.72</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">85.5±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.64</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">2.17±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.39</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">1±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.23</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.09±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.09</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">6.88±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.52</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">14.99</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±1.38</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">36.29</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±2.67</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">497.84</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±65.38</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">52.9±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.69</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">21.7</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±0.5</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">41.1±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">1.07</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-1">
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">G III</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">6.25±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.86</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">10.7±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.61</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">86.17</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±1.01</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">1.75±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.29</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">1±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.35</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.42±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.28</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">7.01±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.5</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">15.04</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±1.22</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">36.85</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±2.21</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">450.17</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±99.74</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">52.8±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.59</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">21.4</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±0.3</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">40.59</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±0.89</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-2">
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">Gr IV</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">5.67±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.42</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">12.67±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">1.11</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">83.5</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±1.6</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">2.75±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.43</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.92±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.33</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.17</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±0.11</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">6.78</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±0.3</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">13.9</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±0.77</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">34.74</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±1.29</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">580.84</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±37.77</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">51.3±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.53</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">20.5</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±0.3</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">39.91</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±0.65</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-1">
						<td rowspan="4">
							<p class="Basic-Paragraph"><span class="CharOverride-12">2</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">Veh</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">icle</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">6.89±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.39</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">12.42</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±0.6</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">85.92</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±0.68</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">1.34±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.25</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.25±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.12</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.09</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±0.09</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">6.57</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±0.47</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">14.49</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±1.14</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">34.84</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±2.23</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">470.17</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±58.68</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">53.2±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.62</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">22±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.3</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">41.48</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±1</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-2">
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">Gr II</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">5.4±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.32</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">12.84</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±0.72</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">84.17</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±0.84</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">2.09±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.16</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.92±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.28</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0±0</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">7.33±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.46</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">15.49</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±1.15</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">37.79</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±2.12</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">531.5±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">56.87</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">51.7±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.65</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">21.1</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±0.4</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">40.79</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±0.77</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-1">
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">G III</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">5.74±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.41</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">11.17</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±0.63</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">85.67</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±1.43</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">1.84±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.65</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.84±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.41</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.34±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.17</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">6.74±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.34</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">13.32</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±0.32</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">37.45</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±2.1</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">539±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">29.62</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">56.3</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±4.6</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">20±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">1.1</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">36.16</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±2.25</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-2">
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">Gr IV</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">6.89±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.15</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">13.59</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±1.37</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">82.42</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±1.73</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">2.67±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.17</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.84±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.31</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.5±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.13</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">6.74</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±0.3</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">14.07</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±0.89</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">34.95</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±1.61</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">526.84</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±54.4</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">51.9±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.68</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">20.8</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±0.4</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">40.12</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±0.64</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-1">
						<td rowspan="4">
							<p class="Basic-Paragraph"><span class="CharOverride-12">5</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">Veh</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">icle</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">6±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">1.07</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">10.92</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±0.74</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">86±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.62</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">2.25±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.58</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.75±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.22</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.09±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.09</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">6.81</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±0.2</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">14.47</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±0.6</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">35.82</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±1.03</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">538.84</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±65.66</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">52.6</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±0.66</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">21.2</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±0.6</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">40.35</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±0.86</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-2">
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">Gr II</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">6.92±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.54</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">12.59</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±0.62</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">84.17</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±0.75</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">2.17±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.34</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.84±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.25</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.42±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.21</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">6.48</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±0.26</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">13.09</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±0.22</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">33.97</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±1.18</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">565.17</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±56.84</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">52.5</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±0.74</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">20.3</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±0.7</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">38.69</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±1.09</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-1">
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">G III</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">7.84±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.71</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">13.75</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±1.55</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">83.17</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±1.76</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">1.92±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.36</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">1±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.35</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.17±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.11</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">6.85</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±0.38</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">14.5</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±0.9</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">35.82</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±1.92</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">591.5±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">65.34</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">52.3</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±0.61</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">21.2</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±0.3</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">40.42</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±0.4</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-2">
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">Gr IV</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">6.9±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.54</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">19.5±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">1.07***</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">77.17</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±1.1**</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">2.17±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.39</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">1.17</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±0.5</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0±0</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">7.01</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±0.21</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">14.17</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±0.7</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">35.3</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±1.21</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">590.34</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±42.84</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">50.3</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±0.28</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">20.2</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±0.4</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">40.05</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±0.64</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-1">
						<td rowspan="4">
							<p class="Basic-Paragraph"><span class="CharOverride-12">9</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">Vehi</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">cle</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">6.75±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.57</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">11.84</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±0.71</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">86±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.54</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">1.42±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.24</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.67±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.28</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.09±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.09</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">6.32</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±0.26</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">13.3±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.28</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">32.35</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±1.02</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">609.67</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±33.37</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">51.4</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±0.82</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">21.2</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±0.8</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">41.23</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±0.95</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-2">
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">Gr II</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">6.37±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.35</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">12.59</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±0.79</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">84±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">1.3</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">2.17±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.43</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.92±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.28</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.34±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.11</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">6.41</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±0.3</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">13.34</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±0.44</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">33.74</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±1.25</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">578.17</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±48.76</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">52.8</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±0.88</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">20.9</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±0.5</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">39.57</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±0.32</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-1">
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">G III</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">5.42±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.32</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">13.67</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±1.52</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">82.67</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±1.39</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">2.67±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.43</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.59±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.21</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.42±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.21</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">6.79±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.36</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">14.24</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±1.13</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">35.04</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±2.25</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">581.34</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±30.75</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">51.5</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±0.74</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">20.9</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±0.5</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">40.48</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±0.54</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-2">
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">Gr IV</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">6.84±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.64</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">23.59±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.89***</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">73±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.49***</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">2.67±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.55</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.67±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.22</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.09±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.09</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">6.62±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.16</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">13.79</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±0.31</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">33.97</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±0.85</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">633.84</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±35.13</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">51.4</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±0.14</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">20.9</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±0.6</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">40.61</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±0.52</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-1">
						<td rowspan="4">
							<p class="Basic-Paragraph"><span class="CharOverride-12">13</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">Vehi</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">cle</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">6.3±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.63</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">12±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.79</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">86±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.5</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">1.59±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.36</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.25±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.12</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.17±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.11</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">6.45±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.46</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">13.84</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±1.26</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">34.4±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">2.02</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">474.67</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±40.67</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">53.7</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±1.8</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">21.3</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±0.7</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">40.03</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±1.96</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-2">
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">Gr II</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">5.84±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.66</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">16.34</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±0.41</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">80.92</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±0.09</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">1.84±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.45</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.67±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.22</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.25±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.12</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">6.73±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.42</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">14.49</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±0.94</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">35.17</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±1.89</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">552.34</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±61.3</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">52.4</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±0.87</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">21.5</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±0.3</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">41.15</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±0.9</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-1">
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">G III</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">6.19±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.55</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">18.17±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.68**</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">78.9</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±0.2**</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">2.25±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.43</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.75±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.39</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.25±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.12</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">6.52±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.12</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">13.52</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±0.27</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">33.79</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±0.54</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">527.67±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">56.93</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">51.8</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±0.31</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">20.7</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±0.1</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">40.01</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±0.3</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-2">
						<td height="59">
							<p class="Basic-Paragraph"><span class="CharOverride-12">Gr IV</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">7.65±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.61</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">23.5±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">1.5***</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">70.75±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.29***</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">2.34±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.52</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">1.34±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.41</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.42±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.16</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">6.97±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.37</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">14.27</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±0.91</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">35.05</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±1.86</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">540.84±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">53.72</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">50.3±</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.64</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">20.5</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±0.6</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">40.64</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-12">±0.62</span></p>
						</td>
					</tr>
				</tbody>
			</table>
			<p class="Figure--and-Table-Heading ParaOverride-1"><span class="CharOverride-5">Values presented as Mean±SE; **p ≤0.01; ***p≤0.001</span></p>
			<p class="Heading-3 ParaOverride-1">&nbsp;</p>
		  <p class="Heading-3 ParaOverride-1">Total Protein, Albumin, Globulin and Albumin Globulin Ratio</p>
			<p class="Body-Text">The effect of chronic exposure of acetamiprid in different doses on plasma total protein, albumin, globulin and albumin globulin ratio of Sprague Dawley rats are presented in <a href="#Table-6-"><span class="Hyperlink">Table</span><span class="Hyperlink"> 6</span></a>, <a href="#Table-7-"><span class="Hyperlink">7</span></a>, <a href="#Table-8-"><span class="Hyperlink">8</span></a> and <a href="#Table-9-"><span class="Hyperlink">9</span></a>,  respectively. </p>
		  <p class="Body-Text">&nbsp;</p>
			<p class="Body-Text ParaOverride-1">There were no significant changes in the levels of plasma total protein in rats of acetamiprid treated groups after 13 week of exposure. Significant increase in plasma albumin level was found in rats of group IV compared to rats of control group after 13 week of acetamiprid exposure.  Although there was no significant increase in the plasma albumin levels of rats of group II, III compared to rats of control group. </p>
		  <p class="Body-Text ParaOverride-1">&nbsp;</p>
			<p class="Figure--and-Table-Heading ParaOverride-1"><span class="CharOverride-4"><a id="Table-2-"></a>Table 2:</span> Effect of acetamiprid on aspartate amino transferase for 13 weeks</p>
			<table width="658" height="165" class="Table-Style-1" id="table-2">
				<colgroup>
					<col />
					<col />
					<col />
					<col />
					<col />
				</colgroup>
				<tbody>
					<tr class="_idGenTableRowColumn-1">
						<td width="107" height="21" />
						<td width="100" />
						<td colspan="3">
							<p class="Basic-Paragraph"><span class="CharOverride-11">          Acetamiprid</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-2">
						<td height="21">
							<p class="Basic-Paragraph"><span class="CharOverride-11">AST (IU/L)</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-11">Vehicle</span></p>
						</td>
						<td width="111">
							<p class="Basic-Paragraph"><span class="CharOverride-11"> 5 mg/kg</span></p>
						</td>
						<td width="156">
							<p class="Basic-Paragraph"><span class="CharOverride-11">20 mg/kg</span></p>
						</td>
						<td width="160">
							<p class="Basic-Paragraph"><span class="CharOverride-11">40 mg/kg</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-1">
						<td height="21">
							<p class="Basic-Paragraph"><span class="CharOverride-12">1 week</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">72±1.16</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">74.17±</span><span class="CharOverride-12">1.86</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">81.34±</span><span class="CharOverride-12">0.89</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">79.34±</span><span class="CharOverride-12">2.25</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-2">
						<td height="21">
							<p class="Basic-Paragraph"><span class="CharOverride-12">2 week</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">75.34±</span><span class="CharOverride-12">1.46</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">74.84±</span><span class="CharOverride-12">1.73</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">78.67±</span><span class="CharOverride-12">2.31</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">88.53±</span><span class="CharOverride-12">4.79</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-1">
						<td height="21">
							<p class="Basic-Paragraph"><span class="CharOverride-12">5 week</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">71.67±</span><span class="CharOverride-12">6.59</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">90.67±</span><span class="CharOverride-12">3.49</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">106.67</span><span class="CharOverride-12">2.58**</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">121.84±</span><span class="CharOverride-12">1.33***</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-2">
						<td height="21">
							<p class="Basic-Paragraph"><span class="CharOverride-12">9 week</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">72.17±</span><span class="CharOverride-12">4.17</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">99.34±</span><span class="CharOverride-12">2.85**</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">110.5±</span><span class="CharOverride-12">3.08***</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">130.84±</span><span class="CharOverride-12">1.43***</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-1">
						<td height="21">
							<p class="Basic-Paragraph"><span class="CharOverride-12">13 week</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">72±2.02</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">110.34±</span><span class="CharOverride-12">3.11**</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">121.84±</span><span class="CharOverride-12">1.43***</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">135.5±</span><span class="CharOverride-12">2.19***</span></p>
						</td>
					</tr>
				</tbody>
			</table>
			<p class="Figure--and-Table-Heading ParaOverride-1">&nbsp;</p>
		  <p class="Figure--and-Table-Heading ParaOverride-1"><span class="CharOverride-5">Values presented as Mean±SE; **p≤0.01; ***p≤0.001 </span> </p>
			<p class="Figure--and-Table-Heading ParaOverride-1">&nbsp;</p>
			<p class="Figure--and-Table-Heading ParaOverride-1">&nbsp;</p>
		  <p class="Figure--and-Table-Heading ParaOverride-1"><span class="CharOverride-4"><a id="Table-3-"></a>Table 3:</span> Effect of acetamiprid on alanine amino transferase for 13 weeks</p>
			<table width="656" height="165" class="Table-Style-1" id="table-3">
				<colgroup>
					<col />
					<col />
					<col />
					<col />
					<col />
				</colgroup>
				<tbody>
					<tr class="_idGenTableRowColumn-1">
						<td />
						<td />
						<td colspan="3">
							<p class="Basic-Paragraph"><span class="CharOverride-11">Acetamiprid</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-2">
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-11">ALT (IU/L)</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-11">Vehicle</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-11"> 5 mg/kg</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-11">20 mg/kg</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-11">40 mg/kg</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-1">
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">1 week</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">33.17± 1.84</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">38±3.06</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">41.17± 2.41</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">44.84± 1.41</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-2">
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">2 week</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">34.17± 1.52</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">41.84± 2.81</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">52.17± 3.55</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">55.17± 2.73</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-1">
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">5 week</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">32.5± 1.26</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">50.84± 3.33*</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">55.34± 1.34**</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">67.5± 2.28***</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-2">
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">9 week</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">31.5± 1</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">52.34± 2.85*</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">60.34± 1.21***</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">81.17± 1.73***</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-1">
						<td height="21">
							<p class="Basic-Paragraph"><span class="CharOverride-12">13 week</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">32.5± 0.89</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">67± 2.74**</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">65.17± 2.04***</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">94.34± 2.77***</span></p>
						</td>
					</tr>
				</tbody>
			</table>
			<p class="Figure--and-Table-Heading ParaOverride-1">&nbsp;</p>
		  <p class="Figure--and-Table-Heading ParaOverride-1"><span class="CharOverride-5">Values presented as Mean±SE; *p≤0.05; **p≤0.01; ***p≤0.001</span> </p>
			<p class="Figure--and-Table-Heading ParaOverride-1">&nbsp;</p>
			<p class="Figure--and-Table-Heading ParaOverride-1">&nbsp;</p>
		  <p class="Figure--and-Table-Heading ParaOverride-1"><span class="CharOverride-4"><a id="Table-4-"></a>Table 4:</span> Effect of acetamiprid on alkaline phosphatase for 13 weeks</p>
			<table width="657" height="163" class="Table-Style-1" id="table-4">
				<colgroup>
					<col />
					<col />
					<col />
					<col />
					<col />
				</colgroup>
				<tbody>
					<tr class="_idGenTableRowColumn-1">
						<td />
						<td />
						<td colspan="3">
							<p class="Basic-Paragraph"><span class="CharOverride-11">Acetamiprid</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-2">
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-11">ALP (IU/L)</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-11">Vehicle</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-11"> 5 mg/kg</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-11">20 mg/kg</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-11">40 mg/kg</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-1">
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">1 week</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">234.67± 6.01</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">237.67± 6.01</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">242.67± 6.01</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">247.67± 6.01</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-2">
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">2 week</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">234± 5.28</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">237± 5.28</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">244± 5.28</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">251± 5.28</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-1">
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">5 week</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">233.67± 6.33</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">239.67± 6.33</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">249.67± 6.33</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">259.67± 6.33*</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-2">
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">9 week</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">235.67± 4.25</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">244.67± 4.25*</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">256.67± 4.25**</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">271.67± 4.25**</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-1">
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">13 week</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">235.17± 4.05</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">248.17± 4.05**</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">263.17± 4.05***</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">278.17± 4.05***</span></p>
						</td>
					</tr>
				</tbody>
			</table>
			<p class="Figure--and-Table-Heading ParaOverride-1">&nbsp;</p>
		  <p class="Figure--and-Table-Heading ParaOverride-1"><span class="CharOverride-5">Values presented as Mean±SE; *p≤0.05; **p≤0.01; ***p≤0.001</span></p>
			<p class="Body-Text ParaOverride-1">&nbsp;</p>
		  <p class="Body-Text ParaOverride-1">Though there were no significant differences on plasma globulin levels but dose dependent decrease in the levels of plasma globulins was observed in the rats of experimental groups over the whole experimental period.</p>
			<p class="Figure--and-Table-Heading ParaOverride-1">&nbsp;</p>
		  <p class="Figure--and-Table-Heading ParaOverride-1"><span class="CharOverride-4"><a id="Table-5-"></a>Table 5:</span> Effect of acetamiprid on plasma glucose for 13 weeks in SD rats</p>
			<table width="658" height="163" class="Table-Style-1" id="table-5">
				<colgroup>
					<col />
					<col />
					<col />
					<col />
					<col />
				</colgroup>
				<tbody>
					<tr class="_idGenTableRowColumn-1">
						<td />
						<td />
						<td colspan="3">
							<p class="Basic-Paragraph"><span class="CharOverride-11">Acetamiprid</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-2">
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-11">Glucose mg/dl</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-11">Vehicle</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-11"> 5 mg/kg</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-11">20 mg/kg</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-11">40 mg/kg</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-1">
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">1 week</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">75.5± 8.9</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">79.5± 4.14</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">86.67± 3.67</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">81.34± 2.57</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-2">
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">2 week</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">81.84± 2.33</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">79±3.42</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">85.17± 3.16</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">80.67± 3.53</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-1">
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">5 week</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">85.5± 4.03</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">85.84± 3.27</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">82.5± 2.75</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">74.5± 4.86*</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-2">
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">9 week</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">84.67± 2.05</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">81.84± 1.86</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">78±3.48</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">73± 4.94*</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-1">
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">13 week</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">83.17± 4.07</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">78± 3.44</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">69.84± 2.75**</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">63± 3.62***</span></p>
						</td>
					</tr>
				</tbody>
			</table>
			<p class="Figure--and-Table-Heading ParaOverride-1">&nbsp;</p>
		  <p class="Figure--and-Table-Heading ParaOverride-1"><span class="CharOverride-5">Values presented as Mean±SE; *p≤0.05;**p≤0.01; ***p≤0.001</span></p>
			<p class="Figure--and-Table-Heading ParaOverride-1">&nbsp;</p>
			<p class="Figure--and-Table-Heading ParaOverride-1">&nbsp;</p>
		  <p class="Figure--and-Table-Heading ParaOverride-1"><span class="CharOverride-4"><a id="Table-6-"></a>Table 6:</span> Effect of acetamiprid on plasma protein for 13 weeks in SD rat</p>
			<table width="657" height="163" class="Table-Style-1" id="table-6">
				<colgroup>
					<col />
					<col />
					<col />
					<col />
					<col />
				</colgroup>
				<tbody>
					<tr class="_idGenTableRowColumn-1">
						<td />
						<td />
						<td colspan="3">
							<p class="Basic-Paragraph"><span class="CharOverride-11">Acetamiprid</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-2">
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-11">Total Protein (g/dl)</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-11">Vehicle</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-11"> 5 mg/kg</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-11">20 mg/kg</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-11">40 mg/kg</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-1">
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">1 week</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">6.74±0.22</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">6.79±0.24</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">6.52±0.29</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">6.84±0.12</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-2">
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">2 week</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">6.74±0.34</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">6.7±0.18</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">6.9±0.14</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">6.95±0.21</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-1">
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">5 week</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">6.9±0.23</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">7.09±0.28</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">6.94±0.2</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">7.17±0.15</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-2">
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">9 week</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">7.04±0.12</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">6.65±0.29</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">6.71±0.3</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">6.94±0.09</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-1">
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">13 week</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">7.09±0.12</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">6.89±0.23</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">6.65±0.25</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">7.34±0.09</span></p>
						</td>
					</tr>
				</tbody>
			</table>
			<p class="Figure--and-Table-Heading ParaOverride-1">&nbsp;</p>
		  <p class="Figure--and-Table-Heading ParaOverride-1"><span class="CharOverride-5">Values presented as Mean±SE</span></p>
			<p class="Figure--and-Table-Heading ParaOverride-1">&nbsp;</p>
			<p class="Figure--and-Table-Heading ParaOverride-1">&nbsp;</p>
		  <p class="Figure--and-Table-Heading ParaOverride-1"><span class="CharOverride-4"><a id="Table-7-"></a>Table 7: </span>Effect of acetamiprid on plasma albumin for 13 weeks in SD rat</p>
			<table width="657" height="165" class="Table-Style-1" id="table-7">
				<colgroup>
					<col />
					<col />
					<col />
					<col />
					<col />
				</colgroup>
				<tbody>
					<tr class="_idGenTableRowColumn-1">
						<td width="132" height="21" />
						<td width="101" />
						<td colspan="3">
							<p class="Basic-Paragraph"><span class="CharOverride-11">Acetamiprid</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-2">
						<td height="21">
							<p class="Basic-Paragraph"><span class="CharOverride-11">Albumin </span><span class="CharOverride-11">(g/dl)</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-11">Vehicle</span></p>
						</td>
						<td width="128">
							<p class="Basic-Paragraph"><span class="CharOverride-11">5 mg/kg</span></p>
						</td>
						<td width="128">
							<p class="Basic-Paragraph"><span class="CharOverride-11">20 mg/kg</span></p>
						</td>
						<td width="144">
							<p class="Basic-Paragraph"><span class="CharOverride-11">40 mg/kg</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-1">
						<td height="21">
							<p class="Basic-Paragraph"><span class="CharOverride-12">1 week</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">3.77±0.09</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">3.8±0.18</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">3.74±0.18</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">3.74±0.09</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-2">
						<td height="21">
							<p class="Basic-Paragraph"><span class="CharOverride-12">2 week</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">3.7±0.09</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">3.74±0.22</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">3.84±0.18</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">3.84±0.14</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-1">
						<td height="21">
							<p class="Basic-Paragraph"><span class="CharOverride-12">5 week</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">3.85±0.25</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">3.72±0.15</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">3.92±0.15</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">4.1±0.26</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-2">
						<td height="21">
							<p class="Basic-Paragraph"><span class="CharOverride-12">9 week</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">3.84±0.22</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">3.97±0.11</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">3.9±0.18</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">4.4±0.21</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-1">
						<td height="21">
							<p class="Basic-Paragraph"><span class="CharOverride-12">13 week</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">3.75±0.21</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">3.87±0.1</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">3.9±0.17</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">4.65±0.26*</span></p>
						</td>
					</tr>
				</tbody>
			</table>
			<p class="Figure--and-Table-Heading ParaOverride-1">&nbsp;</p>
		  <p class="Figure--and-Table-Heading ParaOverride-1"><span class="CharOverride-5">Values presented as Mean±SE; *p≤0.05</span></p>
			<p class="Body-Text ParaOverride-1">&nbsp;</p>
		  <p class="Body-Text ParaOverride-1">The plasma albumin globulin ratio of rats of group IV was higher than rats of control group and overall an increases (non-significant) in the albumin globulin ratio of rats of group II and III compared to rats of control group.</p>
			<p class="Heading-2--History-in-MM-">&nbsp;</p>
		  <p class="Heading-2--History-in-MM-">Total Bilirubin</p>
			<p class="Body-Text ParaOverride-1">The results of daily exposure of acetamiprid for 13 weeks in Sprague Dawley rats in plasma bilirubin level is presented <a href="#Table-10-"><span class="Hyperlink">Table 10</span></a>. The level of total bilirubin in plasma was increased significantly in group III and group IV at 9<span class="CharOverride-8">th</span> week of exposure compared to rats of control group. Although after 13 week of daily exposure to acetamiprid, the plasma level of bilirubin was found to be increased significantly in the treated rats compared rats of control group.</p>
		  <p class="Body-Text ParaOverride-1">&nbsp;</p>
			<p class="Figure--and-Table-Heading ParaOverride-1"><span class="CharOverride-4"><a id="Table-8-"></a>Table 8:</span> Effect of acetamiprid on plasma globulin for 13 weeks in SD rat</p>
			<table width="658" class="Table-Style-1" id="table-8">
				<colgroup>
					<col />
					<col />
					<col />
					<col />
					<col />
				</colgroup>
				<tbody>
					<tr class="_idGenTableRowColumn-1">
						<td width="130" />
						<td width="108" />
						<td colspan="3">
							<p class="Basic-Paragraph"><span class="CharOverride-11">Acetamiprid</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-2">
						<td height="21">
							<p class="Basic-Paragraph"><span class="CharOverride-11">Globulin </span><span class="CharOverride-11">(g/dl)</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-11">Vehicle</span></p>
						</td>
						<td width="131">
							<p class="Basic-Paragraph"><span class="CharOverride-11"> 5 mg/kg</span></p>
						</td>
						<td width="131">
							<p class="Basic-Paragraph"><span class="CharOverride-11">20 mg/kg</span></p>
						</td>
						<td width="134">
							<p class="Basic-Paragraph"><span class="CharOverride-11">40 mg/kg</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-1">
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">1 week</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">2.97±0.24</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">2.99±0.3</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">2.79±0.44</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">3.1±0.18</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-2">
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">2 week</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">3.04±0.29</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">2.97±0.36</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">3.07±0.25</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">3.12±0.19</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-1">
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">5 week</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">3.05±0.31</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">3.37±0.19</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">3.02±0.3</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">3.07±0.18</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-2">
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">9 week</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">3.2±0.18</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">2.69±0.34</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">2.8±0.42</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">2.54±0.23</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-1">
						<td height="21">
							<p class="Basic-Paragraph"><span class="CharOverride-12">13 week</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">3.34±0.26</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">3.02±0.27</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">2.75±0.3</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">2.69±0.3</span></p>
						</td>
					</tr>
				</tbody>
			</table>
			<p class="Figure--and-Table-Heading ParaOverride-1">&nbsp;</p>
		  <p class="Figure--and-Table-Heading ParaOverride-1"><span class="CharOverride-5">Values presented as Mean±SE</span></p>
			<p class="Figure--and-Table-Heading ParaOverride-1">&nbsp;</p>
			<p class="Figure--and-Table-Heading ParaOverride-1">&nbsp;</p>
		  <p class="Figure--and-Table-Heading ParaOverride-1"><span class="CharOverride-4"><a id="Table-9-"></a>Table 9:</span> Effect of acetamiprid on albumin: globulin ratio for 13 weeks in SD rat</p>
			<table width="658" height="163" class="Table-Style-1" id="table-9">
				<colgroup>
					<col />
					<col />
					<col />
					<col />
					<col />
				</colgroup>
				<tbody>
					<tr class="_idGenTableRowColumn-1">
						<td />
						<td />
						<td colspan="3">
							<p class="Basic-Paragraph"><span class="CharOverride-11">Acetamiprid</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-2">
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-11">Albumin/ Globulin</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-11">Vehicle</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-11">5 mg/kg</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-11">20 mg/kg</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-11">40 mg/kg</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-1">
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">1 week</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">1.32±0.12</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">1.35±0.16</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">1.62±0.38</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">1.23±0.09</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-2">
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">2 week</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">1.27±0.11</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">1.48±0.37</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">1.31±0.13</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">1.26±0.09</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-1">
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">5 week</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">1.4±0.27</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">1.12±0.07</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">1.39±0.19</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">1.38±0.15</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-2">
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">9 week</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">1.24±0.13</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">1.6±0.18</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">1.59±0.29</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">1.86±0.28</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-1">
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">13 week</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">1.18±0.14</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">1.35±0.16</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">1.52±0.2</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">1.93±0.37</span></p>
						</td>
					</tr>
				</tbody>
			</table>
			<p class="Figure--and-Table-Heading ParaOverride-1">&nbsp;</p>
		  <p class="Figure--and-Table-Heading ParaOverride-1"><span class="CharOverride-5">Values presented as Mean±SE</span></p>
			<p class="Figure--and-Table-Heading ParaOverride-1">&nbsp;</p>
			<p class="Figure--and-Table-Heading ParaOverride-1">&nbsp;</p>
		  <p class="Figure--and-Table-Heading ParaOverride-1"><span class="CharOverride-4"><a id="Table-10-"></a>Table 10:</span> Effect of acetamiprid on total bilirubin for 13 weeks in SD rat</p>
			<table width="658" height="163" class="Table-Style-1" id="table-10">
				<colgroup>
					<col />
					<col />
					<col />
					<col />
					<col />
				</colgroup>
				<tbody>
					<tr class="_idGenTableRowColumn-1">
						<td />
						<td />
						<td colspan="3">
							<p class="Basic-Paragraph"><span class="CharOverride-11">Acetamiprid</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-2">
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-11">Total Bilirubin (mg/dl)</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-11">Vehicle</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-11">5 mg/kg</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-11">20 mg/kg</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-11">40 mg/kg</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-1">
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">1 week</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.53±0.13</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.5±0.14</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.6±0.06</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.55±0.11</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-2">
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">2 week</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.47±0.09</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.65±0.06</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.79±0.06</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.84±0.17</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-1">
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">5 week</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.64±0.06</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.8±0.07</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">1.14±0.13</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">1.09±0.16</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-2">
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">9 week</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.55±0.09</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">1.09±0.09</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">1.27±0.1*</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">1.5±0.13**</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-1">
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">13 week</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.72±0.11</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.84±0.11</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">1.72±0.11**</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">2.6±0.4***</span></p>
						</td>
					</tr>
				</tbody>
			</table>
			<p class="Figure--and-Table-Heading ParaOverride-1">&nbsp;</p>
		  <p class="Figure--and-Table-Heading ParaOverride-1"><span class="CharOverride-5">Values presented as Mean±SE; *p≤0.05; **p≤0.01; ***p≤0.001</span></p>
			<p class="Figure--and-Table-Heading ParaOverride-1">&nbsp;</p>
			<p class="Figure--and-Table-Heading ParaOverride-1">&nbsp;</p>
		  <p class="Figure--and-Table-Heading ParaOverride-1"><span class="CharOverride-4"><a id="Table-11-"></a>Table 11:</span> Effect of acetamiprid on creatinine for 13 weeks in SD rat</p>
			<table width="657" height="165" class="Table-Style-1" id="table-11">
				<colgroup>
					<col />
					<col />
					<col />
					<col />
					<col />
				</colgroup>
				<tbody>
					<tr class="_idGenTableRowColumn-1">
						<td height="21" />
						<td />
						<td colspan="3">
							<p class="Basic-Paragraph"><span class="CharOverride-11">Acetamiprid</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-2">
						<td height="21">
							<p class="Basic-Paragraph"><span class="CharOverride-11">Creatine</span><span class="CharOverride-11">(mg/dl)</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-11">Vehicle</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-11">5 mg/kg</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-11">20 mg/kg</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-11">40 mg/kg</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-1">
						<td height="21">
							<p class="Basic-Paragraph"><span class="CharOverride-12">1 week</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.47±0.05</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.52±0.04</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.5±0.03</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.69±0.05</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-2">
						<td height="21">
							<p class="Basic-Paragraph"><span class="CharOverride-12">2 week</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.5±0.09</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.54±0.05</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.57±0.05</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.79±0.04</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-1">
						<td height="21">
							<p class="Basic-Paragraph"><span class="CharOverride-12">5 week</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.45±0.06</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.59±0.07</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.85±0.04**</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">1.0±0.05**</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-2">
						<td height="21">
							<p class="Basic-Paragraph"><span class="CharOverride-12">9 week</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.52±0.07</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.64±0.07</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.88±0.05**</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">1.1±0.03**</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-1">
						<td height="21">
							<p class="Basic-Paragraph"><span class="CharOverride-12">13 week</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.53±0.05</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.69±0.11</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">0.98±0.03**</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">1.6±0.04***</span></p>
						</td>
					</tr>
				</tbody>
			</table>
			<p class="Figure--and-Table-Heading ParaOverride-1">&nbsp;</p>
		  <p class="Figure--and-Table-Heading ParaOverride-1"><span class="CharOverride-5">Values presented as Mean±SE; **p≤0.01; ***p≤0.001</span></p>
			<p class="Heading-2--History-in-MM-">&nbsp;</p>
		  <p class="Heading-2--History-in-MM-">Creatinine</p>
			<p class="Body-Text ParaOverride-1">The effect of the acetamiprid exposure after daily oral administration for 13 weeks to Sprague Dawley rats on plasma creatinine is shown in <a href="#Table-11-"><span class="Hyperlink">Table 11</span></a>. There was increase in creatinine levels in a dose dependent manner in acetamiprid treated rats except in rats of group II as compared to rats of control group (group I) from 5<span class="CharOverride-8">th</span> week onward. The same trend was found upto 13 weeks of exposure to acetamiprid where creatinine was increased significantly to 1.56 mg/dl in group IV (acetamiprid 40 mg/kg).</p>
		  <p class="Body-Text ParaOverride-1">&nbsp;</p>
			<p class="Heading-2--History-in-MM-">Blood Urea Nitrogen</p>
			<p class="Body-Text ParaOverride-1">The effect of acetamiprid on blood urea nitrogen in SD rats is presented in <a href="#Table-12-"><span class="Hyperlink">Table 12</span></a>. There was significant (**p≤0.01) increase in blood urea nitrogen level in rats of group IV only at 9<span class="CharOverride-8">th</span> week of exposure compared to rats of control group. Augmented level of BUN was found in rats of group III and IV at the end of 13 week exposure. </p>
		  <p class="Body-Text ParaOverride-1">&nbsp;</p>
			<p class="Figure--and-Table-Heading ParaOverride-1"><span class="CharOverride-4"><a id="Table-12-"></a>Table 12:</span> Effect of acetamiprid on blood urea nitrogen for 13 weeks in SD rat</p>
			<table width="658" height="165" class="Table-Style-1" id="table-12">
				<colgroup>
					<col />
					<col />
					<col />
					<col />
					<col />
				</colgroup>
				<tbody>
					<tr class="_idGenTableRowColumn-1">
						<td height="21" />
						<td />
						<td colspan="3">
							<p class="Basic-Paragraph"><span class="CharOverride-11">Acetamiprid</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-2">
						<td height="21">
							<p class="Basic-Paragraph"><span class="CharOverride-11">BUN </span><span class="CharOverride-11">(mg/dl)</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-11">Vehicle</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-11"> 5 mg/kg</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-11">20 mg/kg</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-11">40 mg/kg</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-1">
						<td height="21">
							<p class="Basic-Paragraph"><span class="CharOverride-12">1 week</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">22.17±0.95</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">23.34±1.03</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">22.8±1.67</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">21.17±1.56</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-2">
						<td height="21">
							<p class="Basic-Paragraph"><span class="CharOverride-12">2 week</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">22±1.19</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">23.67±1.57</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">21.1±1.05</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">24±0.94</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-1">
						<td height="21">
							<p class="Basic-Paragraph"><span class="CharOverride-12">5 week</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">21.5±1.44</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">20.5±1.09</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">21.5±1.39</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">26.5±1.26</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-2">
						<td height="21">
							<p class="Basic-Paragraph"><span class="CharOverride-12">9 week</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">22.67±0.92</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">21.84±1.2</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">22.17±0.9</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">33±1.16**</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-1">
						<td height="21">
							<p class="Basic-Paragraph"><span class="CharOverride-12">13 week</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">22.84±0.88</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">23±1.53</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">30±1.81*</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">40.3±0.9***</span></p>
						</td>
					</tr>
				</tbody>
			</table>
			<p class="Figure--and-Table-Heading ParaOverride-1">&nbsp;</p>
		  <p class="Figure--and-Table-Heading ParaOverride-1"><span class="CharOverride-5">Values presented as Mean±SE; **p≤0.05; **p≤0.01; ***p≤0.001  </span></p>
			<p class="Heading-2--History-in-MM-">&nbsp;</p>
		  <p class="Heading-2--History-in-MM-">Calcium</p>
			<p class="Body-Text">Mean values of plasma concentration of calcium is given in <a href="#Table-13-"><span class="Hyperlink">Table 13</span></a>. There was no alteration in the level of plasma calcium in acetamiprid treated rats compared to control rat up to 9<span class="CharOverride-8">th</span> week of daily oral acetamiprid exposure. But at 13<span class="CharOverride-8">th</span> week of acetamiprid exposure caused a significant reduction in plasma level of calcium in group IV as compared to group I.</p>
		  <p class="Body-Text">&nbsp;</p>
			<p class="Figure--and-Table-Heading ParaOverride-1"><span class="CharOverride-4"><a id="Table-13-"></a>Table 13:</span> Effect of acetamiprid on plasma calcium for 13 weeks in SD rat</p>
			<table width="658" height="165" class="Table-Style-1" id="table-13">
				<colgroup>
					<col />
					<col />
					<col />
					<col />
					<col />
				</colgroup>
				<tbody>
					<tr class="_idGenTableRowColumn-1">
						<td height="21" />
						<td />
						<td colspan="3">
							<p class="Basic-Paragraph"><span class="CharOverride-11">Acetamiprid</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-2">
						<td height="21">
							<p class="Basic-Paragraph"><span class="CharOverride-11">Calcium </span><span class="CharOverride-11">(mg/dl)</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-11">Vehicle</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-11">5 mg/kg</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-11">20 mg/kg</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-11">40 mg/kg</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-1">
						<td height="21">
							<p class="Basic-Paragraph"><span class="CharOverride-12">1 week</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">9.45±0.79</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">10.2±0.31</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">10.57±0.43</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">10.17±0.62</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-2">
						<td height="21">
							<p class="Basic-Paragraph"><span class="CharOverride-12">2 week</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">10±1</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">10.1±0.71</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">10.09±0.31</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">8.95±0.52</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-1">
						<td height="21">
							<p class="Basic-Paragraph"><span class="CharOverride-12">5 week</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">10.17±0.88</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">10.7±0.71</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">9.19±0.3</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">8.29±0.45</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-2">
						<td height="21">
							<p class="Basic-Paragraph"><span class="CharOverride-12">9 week</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">10.34±0.78</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">10.2±0.72</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">7.84±0.24</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">7.77±0.46</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-1">
						<td height="21">
							<p class="Basic-Paragraph"><span class="CharOverride-12">13 week</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">10.17±1.08</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">9.19±0.31</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">7.19±0.24</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">6.59±0.41*</span></p>
						</td>
					</tr>
				</tbody>
			</table>
			<p class="Figure--and-Table-Heading ParaOverride-1">&nbsp;</p>
			<p class="Figure--and-Table-Heading ParaOverride-1"><span class="CharOverride-5">Values presented as Mean±SE; **p≤0.05</span></p>
		  <p class="Figure--and-Table-Heading ParaOverride-1">&nbsp;</p>
			<p class="Heading-2--History-in-MM-">Phosphorus</p>
			<p class="Body-Text ParaOverride-1">There was no significant difference in plasma phosphorus concentration of acetamiprid-administered groups as compared to control group upto 5<span class="CharOverride-8">th</span> week of administration. But at 9<span class="CharOverride-8">th</span> week it was found to be significantly (p≤0.05) increased in group IV only compared to rats of control group. At 13 weeks of exposure group III and group IV showed significant increase in plasma phosphorus concentration compared to control group (<a href="#Table-14-"><span class="Hyperlink">Table 14</span></a>). </p>
		  <p class="Body-Text ParaOverride-1">&nbsp;</p>
			<p class="Figure--and-Table-Heading ParaOverride-1"><span class="CharOverride-4"><a id="Table-14-"></a>Table 14:</span> Effect of acetamiprid on plasma phosphorus for 13 weeks in SD rat</p>
			<table width="656" height="165" class="Table-Style-1" id="table-14">
				<colgroup>
					<col />
					<col />
					<col />
					<col />
					<col />
				</colgroup>
				<tbody>
					<tr class="_idGenTableRowColumn-1">
						<td height="21" />
						<td />
						<td colspan="3">
							<p class="Basic-Paragraph"><span class="CharOverride-11">Acetamiprid</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-2">
						<td height="21">
							<p class="Basic-Paragraph"><span class="CharOverride-11">Phosphorus </span><span class="CharOverride-11">(mg/dl)</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-11">Vehicle</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-11">5 mg/kg</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-11">20 mg/kg</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-11">40 mg/kg</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-1">
						<td height="21">
							<p class="Basic-Paragraph"><span class="CharOverride-12">1 week</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">6.67±0.67</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">6.34±0.5</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">6.17±0.56</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">6.34±0.43</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-2">
						<td height="21">
							<p class="Basic-Paragraph"><span class="CharOverride-12">2 week</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">6.84±0.75</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">6.67±0.5</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">6.67±0.48</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">7.17±0.31</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-1">
						<td height="21">
							<p class="Basic-Paragraph"><span class="CharOverride-12">5 week</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">6.84±0.61</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">6.67±0.3</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">6.95±0.27</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">7.72±0.17</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-2">
						<td height="21">
							<p class="Basic-Paragraph"><span class="CharOverride-12">9 week</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">6.5±0.57</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">7±0.35</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">7.5±0.25</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">8.39±0.32*</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-1">
						<td height="21">
							<p class="Basic-Paragraph"><span class="CharOverride-12">13 week</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">6.34±0.43</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">7.34±0.2</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">8.5±0.27**</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">10.3±0.3***</span></p>
						</td>
					</tr>
				</tbody>
			</table>
			<p class="Figure--and-Table-Heading ParaOverride-1">&nbsp;</p>
		  <p class="Figure--and-Table-Heading ParaOverride-1"><span class="CharOverride-5">Values presented as Mean±SE; *p≤0.05; **p≤0.01; ***p≤0.001</span></p>
			<p class="Heading-2--History-in-MM-">&nbsp;</p>
		  <p class="Heading-2--History-in-MM-">Sodium </p>
			<p class="Body-Text ParaOverride-1">A significant (P≤0.05) increase in sodium was observed in rats of group III &amp; IV as compared to control rats in 5<span class="CharOverride-8">th</span> weeks of acetamiprid administration. Nine weeks of exposure to acetamiprid, caused a significant increase in plasma sodium level in a dose dependent manner. There was also dose dependent and significant increase in the sodium level in all treated animal compared to rats of control animal.  Data was presented in <a href="#Table-15-"><span class="Hyperlink">Table 15</span></a>.</p>
		  <p class="Body-Text ParaOverride-1">&nbsp;</p>
			<p class="Figure--and-Table-Heading ParaOverride-1"><span class="CharOverride-4"><a id="Table-15-"></a>Table 15:</span> Effect of acetamiprid on plasma sodium for 13 weeks in SD rat</p>
			<table width="658" height="163" class="Table-Style-1" id="table-15">
				<colgroup>
					<col />
					<col />
					<col />
					<col />
					<col />
				</colgroup>
				<tbody>
					<tr class="_idGenTableRowColumn-1">
						<td />
						<td />
						<td colspan="3">
							<p class="Basic-Paragraph"><span class="CharOverride-11">Acetamiprid</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-2">
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-11">Sodium (mEq/l)</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-11">Vehicle</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-11">5 mg/kg</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-11">20 mg/kg</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-11">40 mg/kg</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-1">
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">1 week</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">152.34 ±8.5</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">152.34± 11.34</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">161.34± 11.21</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">167.34± 10.81</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-2">
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">2 week</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">149.34 ±12.28</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">154.17± 12.59</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">171.17± 11.71</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">177.17± 13.08</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-1">
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">5 week</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">151.34 ±6.03</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">165.67± 9.83</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">189± 7.88**</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">203.67± 5.1***</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-2">
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">9 week</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">150.17 ±8.89</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">181.17± 10.86**</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">203± 3.87***</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">222.17± 11.5***</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-1">
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">13 week</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">149.67 ±1.12</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">202.84± 2.03**</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">232.84± 3.22***</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">250.5± 2.44***</span></p>
						</td>
					</tr>
				</tbody>
			</table>
			<p class="Figure--and-Table-Heading ParaOverride-1">&nbsp;</p>
		  <p class="Figure--and-Table-Heading ParaOverride-1"><span class="CharOverride-5">Values presented as Mean±SE; **p≤0.01; ***p≤0.001</span></p>
			<p class="Heading-2--History-in-MM-">&nbsp;</p>
		  <p class="Heading-2--History-in-MM-">Potassium</p>
			<p class="Body-Text">The effect of the acetamiprid exposure after daily oral administration for 13 weeks to Sprague Dawley rats on plasma potassium is shown in <a href="#Table-16-"><span class="Hyperlink">Table 16</span></a>. There was significant (***p≤0.001) increase in plasma potassium level in only group IV in 9<span class="CharOverride-8">th</span> week, compared to rats of control group. Although there was no changes recorded up to 5 week of acetamiprid oral administration in SD rat but at 13 week there was dose dependent significant (*p≤0.05) increase in the level of plasma potassium in treated rats compared to control rat.</p>
		  <p class="Body-Text">&nbsp;</p>
			<p class="Figure--and-Table-Heading ParaOverride-1"><span class="CharOverride-4"><a id="Table-16-"></a>Table 16:</span> Effect of acetamiprid on plasma potassium for 13 weeks in SD rat</p>
			<table width="658" height="165" class="Table-Style-1" id="table-16">
				<colgroup>
					<col />
					<col />
					<col />
					<col />
					<col />
				</colgroup>
				<tbody>
					<tr class="_idGenTableRowColumn-1">
						<td width="133" height="21" />
						<td width="104" />
						<td colspan="3">
							<p class="Basic-Paragraph"><span class="CharOverride-11">Acetamiprid</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-2">
						<td height="21">
							<p class="Basic-Paragraph"><span class="CharOverride-11">Potassium </span><span class="CharOverride-11">(mEq/L)</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-11">Vehicle</span></p>
						</td>
						<td width="122">
							<p class="Basic-Paragraph"><span class="CharOverride-11">5 mg/kg</span></p>
						</td>
						<td width="137">
							<p class="Basic-Paragraph"><span class="CharOverride-11">20 mg/kg</span></p>
						</td>
						<td width="138">
							<p class="Basic-Paragraph"><span class="CharOverride-11">40 mg/kg</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-1">
						<td height="21">
							<p class="Basic-Paragraph"><span class="CharOverride-12">1 week</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">4.09±0.24</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">4.09±0.24</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">4.17±0.31</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">4.17±0.53</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-2">
						<td height="21">
							<p class="Basic-Paragraph"><span class="CharOverride-12">2 week</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">4.07±0.24</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">4.07±0.39</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">4.34±0.48</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">5.17±0.46</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-1">
						<td height="21">
							<p class="Basic-Paragraph"><span class="CharOverride-12">5 week</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">4.17±0.25</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">4.34±0.22</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">4.59±0.4</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">5.25±0.2</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-2">
						<td height="21">
							<p class="Basic-Paragraph"><span class="CharOverride-12">9 week</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">4.01±0.29</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">4.42±0.24</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">5±0.23</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">6.7±0.4***</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-1">
						<td height="21">
							<p class="Basic-Paragraph"><span class="CharOverride-12">13 week</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">4.09±0.31</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">5.24±0.2*</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">6.6±0.2***</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">8.9±0.3***</span></p>
						</td>
					</tr>
				</tbody>
			</table>
			<p class="Figure--and-Table-Heading ParaOverride-1">&nbsp;</p>
		  <p class="Figure--and-Table-Heading ParaOverride-1"><span class="CharOverride-5">Values presented as Mean±SE; *p≤0.05; ***p≤0.001</span></p>
			<p class="Heading-2--History-in-MM-">&nbsp;</p>
		  <p class="Heading-2--History-in-MM-">Chlorine</p>
			<p class="Body-Text ParaOverride-1">Mean values of plasma concentration of chlorine was presented in <a href="#Table-17-"><span class="Hyperlink">Table 17</span></a>. A dose dependent hyperchloremia was found to be observed in acetamiprid treated rat in this present experiment. There was significant increase in plasma chlorine level in all acetamiprid treated rat from 9<span class="CharOverride-8">th</span> week onwards in comparison with control rat.</p>
		  <p class="Body-Text ParaOverride-1">&nbsp;</p>
			<p class="Figure--and-Table-Heading ParaOverride-1"><span class="CharOverride-4"><a id="Table-17-"></a>Table 17:</span> Effect of acetamiprid on plasma chlorine for 13 weeks in SD rat </p>
			<table width="657" height="163" class="Table-Style-1" id="table-17">
				<colgroup>
					<col />
					<col />
					<col />
					<col />
					<col />
				</colgroup>
				<tbody>
					<tr class="_idGenTableRowColumn-1">
						<td />
						<td />
						<td colspan="3">
							<p class="Basic-Paragraph"><span class="CharOverride-11">Acetamiprid</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-2">
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-11">Chlorine(mEq/l)</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-11">Vehicle</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-11">5 mg/kg</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-11">20mg/kg</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-11">40mg/kg</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-1">
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">1 week</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">105.17 ±1.31</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">107.84 ±1.63</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">108.67 ±2.28</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">110± 2.47</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-2">
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">2 week</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">103.67 ±1.36</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">113.17 ±2.68</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">126.17± 2.5</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">131.17 ±1.54</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-1">
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">5 week</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">105.5 ±1.41</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">128± 1.4</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">136± 2.44**</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">140.5± 1.53***</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-2">
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">9 week</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">103.34 ±1.55</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">133.84 ±1.45**</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">145.5± 2.84***</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">147.84± 2.29***</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-1">
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">13 week</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">104.34 ±2.37</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">135.5 ±1.26**</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">147.67± 3.55***</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-12">156.67± 3.21***</span></p>
						</td>
					</tr>
				</tbody>
			</table>
			<p class="Figure--and-Table-Heading ParaOverride-1">&nbsp;</p>
		  <p class="Figure--and-Table-Heading ParaOverride-1"><span class="CharOverride-5">Values presented as Mean±SE; **p≤0.01; ***p≤0.001</span></p>
			<p class="Heading-1--Introduction----">&nbsp;</p>
			<p class="Heading-1--Introduction----">DISCUSSIONS</p>
		  <p class="Heading-1--Introduction----">&nbsp;</p>
			<p class="Heading-2--History-in-MM-">Body Weight </p>
			<p class="Body-Text ParaOverride-1">The results in the present study of decrease in the body weight in SD rats following oral exposure of acetamiprid were in agreement with <a href="#Koller-LD--Exon-JH--Roan-JG--1976"><span class="Hyperlink">Koller et al. (1976)</span></a>, who reported decreased body weight gain in mice exposed to pesticide, leptophos @ 0, 10, 100 and 500 ppm for 12 weeks. Body weight was significantly decreased in male and female mice in fenvalerate toxicity for 2 years (<a href="#Parker-GM--McGullough-GB--Gellatly-JB--Johnston-GD--1983-."><span class="Hyperlink">Parker et al., 1983</span></a>). However <a href="#Varshneya-C--Singh-T--Sharma-LD--Bahga-HS--Garg-SK--1992-"><span class="Hyperlink">Varshneya et al. (1992)</span></a> did not find any effect of cypermethrin in rats on body weight gain. However, <a href="#Mondal-S--Ghosh-2012"><span class="Hyperlink">Mondal et al. (2010)</span></a> reported decrease in body weight gain in subacute acetamiprid toxicity. </p>
		  <p class="Body-Text ParaOverride-1">&nbsp;</p>
			<p class="Body-Text">In the present study, reduced body weight gain might be an indication of direct toxicity or stressogenic activity of these compounds (<a href="#Gowda--Uppal--Garg-1983"><span class="Hyperlink">Gowda et al., 1983</span></a>; <a href="#Gowda-H--Uppal-RP--Garg-BD--1985"><span class="Hyperlink">1984</span></a> and <a href="#Gowda-H--Uppal-RP--Garg-BD--1984"><span class="Hyperlink">1985</span></a>) in GI tract resulting in decreased appetite and absorption (<a href="#Bhelonde-JJ--Ghosh-RC--2004-"><span class="Hyperlink">Bhelonde and Ghosh, 2004</span></a>). The reduction in body weight could also be attributed to anorectic properties of acetamiprid. </p>
		  <p class="Body-Text">&nbsp;</p>
			<p class="Heading-2--History-in-MM-">Feed Consumption</p>
			<p class="Body-Text ParaOverride-1">The reduced feed intake in treated animal compare to control rat in the present experiment is accordance with <a href="#Mondal-S--Ghosh-2010"><span class="Hyperlink">Mondal et al. (2010)</span></a> who reported less feed consumption in acetamiprid intoxicated rat. <a href="#Patel-NN--Ghodasara-DJ--Pandey-S--Ghodasara-PD--Khorajiya-JH--Joshi-BP--Dave-CJ--2014"><span class="Hyperlink">Patel et al. (2014)</span></a> also reported reduction in feed consumption in Wistar rat due to stressogenic activity of chemicals which corroborate the results of present findings. </p>
		  <p class="Body-Text ParaOverride-1">&nbsp;</p>
			<p class="Heading-2--History-in-MM-">Haematology</p>
			<p class="Body-Text ParaOverride-1">In the present study, acetamiprid, dissolved in water caused a statistically significant increase (P≤0.05) in neutrophil level but significant decrease in lymphocyte percentage count, thus acetamiprid could produce lymphocytopenia if administered orally for 13 weeks. It was suggested that compounds having benzene ring or other ring structure acted as hapten that combined with a protein constituent of leukocytes to form an antigen to which animal developed antibodies which was toxic to leukocytes causing either lysis or agglutination (<a href="#Benjamin-MM--1978"><span class="Hyperlink">Benjamin, 1978</span></a>). Acetamiprid was also a ring structure compound and thus might have caused leukocytopenia. The acetamiprid might have also direct cytotoxic effect on leukocyte as also suggested in gentamicin toxicity in guinea pigs (<a href="#Gupta-RP--Verma-PC--1998"><span class="Hyperlink">Gupta and Verma, 1998</span></a>). It therefore showed that with continuous administration of this insecticide to animal the principle function of phagocytes, which was to defend against invading microorganisms by ingesting and destroying them, thus contributing to cellular inflammatory processes, might be compromised (<a href="#Staub-NC--1994-"><span class="Hyperlink">Staub, 1994</span></a>). It should be noted that acetamiprid caused a significant decrease in the level of lymphocyte in all treated groups with significant increase in the level of neutrophils. Continuous exposure to this insecticide caused to lymphocytopaenia, which might have an immunosuppressive effect. The observed neutrophilia and lymphocytopenia might have occurred due to the adverse effect of insecticide on the normal functioning of bone marrow, stress (<a href="#Jain-NC--1986"><span class="Hyperlink">Jain, 1986</span></a>) and/or due to varied factors responsible for the normal leukocyte balance (<a href="#Platt-WR--1979"><span class="Hyperlink">Platt, 1979</span></a>).</p>
		  <p class="Body-Text ParaOverride-1">&nbsp;</p>
			<p class="Heading-2--History-in-MM-">Blood Chemistry</p>
			<p class="Body-Text">Significant increase in plasma AST activity in acetamiprid treated rats suggested an increased respiratory burst and mitochondrial involvement, as AST was chiefly a mitochondrial enzyme. Mitochondrion plays an important role in maintaining hepatocyte integrity and function, which might be hampered due to excessive physiologic stress (<a href="#Hassanein-T--2004-"><span class="Hyperlink">Hassanein, 2004</span></a>). Activity of AST was high in acute and chronic liver injury (<a href="#Tennant-BC--1997"><span class="Hyperlink">Tennant, 1997</span></a>). Elevation in the AST could be associated with cell necrosis of many tissues. Pathology involving the skeletal or cardiac muscle and/or the hepatic parenchyma, allowed the leakage of large amount of this enzyme into blood (<a href="#Kaneko-JJ--1980-."><span class="Hyperlink">Kaneko, 1980</span></a>). The elevation in AST produced by acetamiprid is an indication of tissue damage. <a href="#Mondal-S--Ghosh-RC--Karnam-SS--Purohit-K--2014-."><span class="Hyperlink">Mondal et al. (2014)</span></a> also reported increased AST activity in female Wistar rat after acetamiprid administration which was in well agreements with the present finding.  </p>
		  <p class="Body-Text">&nbsp;</p>
			<p class="Body-Text ParaOverride-1">Alanine amino transferase was a key cytoplasmic enzyme present in liver and other cells. It was particularly useful in measuring hepatic necrosis, especially in small animals (<a href="#Cornelius-CE--1989-."><span class="Hyperlink">Cornelius, 1989</span></a>). Alanine amino transferase was considered as a marker of hepato cellular damage and in general ALT was considered a more sensitive indicator of liver cell injury than AST (<a href="#Oser-BL--1976"><span class="Hyperlink">Oser, 1976</span></a>). Though AST and ALT were not known to have any function in the plasma, but their increase level in the blood indicate cellular damage and increased membrane permeability (<a href="#Ramazzotto-LJ--Carlin-R--1978-"><span class="Hyperlink">Ramazzotto and Carlin, 1978</span></a>) and their altered metabolism (<a href="#Dinman-BD--Hamdi-EA--Fox-CF--Frazola-WJ--1963"><span class="Hyperlink">Dinman et al., 1963</span></a>). Since ALT was one of the specific assayable liver enzymes, its elevated level in the study may indicate hepatic damage caused by oral administration of acetamiprid.  Although it was difficult to point the damage to any particular organ by acetamiprid, but increased levels of aminotransferases in rats may be attributed to liver damage, as a primary organ of biotransformation of acetamiprid.</p>
		  <p class="Body-Text ParaOverride-1">&nbsp;</p>
			<p class="Body-Text">Alkaline phosphatase, a brush border enzyme with its organic phosphatase esters mediated membrane transport (<a href="#Gold-FS--Esser-E--Novikoft-AB--1964-"><span class="Hyperlink">Gold et al., 1964</span></a>). They were zinc metallo enzymes that are composed of two identical subunits arranged around an active centre. It was known to be involved in a variety of activities such as permeability, growth and cell differentiation (<a href="#Shaffi-SA--Jafri-AK--Khawaja-DK--1974"><span class="Hyperlink">Shaffi et al., 1974</span></a>). The elevation in plasma in ALP activities in SD rats are not in accordance with the findings of <a href="#Premlata--2001"><span class="Hyperlink">Premlata (2001)</span></a> who reported a decline of ALP activity in rats following 28 days of oral administration of imidacloprid. Release of ALP usually occurs due to its increased synthesis brought about by variety of liver conditions (<a href="#Seetharam-S--Sussman-NL--Komoda-T-Alpers-DH--1986-"><span class="Hyperlink">Seetharam et al., 1986</span></a>). Significant increased levels of ALP in acetamiprid treated rats suggested alteration in membrane structure, as ALP was a plasma membrane enzyme.</p>
		  <p class="Body-Text">&nbsp;</p>
			<p class="Body-Text ParaOverride-1">In the present study hypoglycemia was observed on 5<span class="CharOverride-8">th</span> week and there was a dose dependent decrease in glucose concentration after 5<span class="CharOverride-8">th</span> week of oral administration of acetamiprid. The results of the present study showed that dose related decrease in level of blood glucose was in agreement with the observation of <a href="#Jain-SK--Punia-JS--2006"><span class="Hyperlink">Jain and Punia (2006) </span></a>in imidacloprid treated rats. Studies on rats have indicated that thyroid could be sensitive to acetamiprid. In 1998, US EPA report has indicated that imidacloprid could an affect thyroid function in animals, which may cause decrease in blood glucose levels. As acetamiprid and imidacloprid both are nitroguanidine insecticide and have structural similarity, acetamiprid can also affect thyroid function. Hypoglysemia was also reported by <a href="#Mondal-S--Ghosh-RC--Karnam-SS--Purohit-K--2014-."><span class="Hyperlink">Mondal et al. (2014)</span></a> in acetamiprid induced toxicity in female wistar rat.</p>
		  <p class="Body-Text ParaOverride-1">&nbsp;</p>
			<p class="Body-Text ParaOverride-1">The acetamiprid caused significant (P ≤ 0.05) elevation in the levels of albumin with decreased globulin. The increase in albumin may be due to dehydration following refusal of animals to drink water as a result of oral administration of acetamiprid (<a href="#Mondal-S--Ghosh-2012"><span class="Hyperlink">Mondal et al., 2012</span></a>). Decreased levels of globulin indicate that the immune competence of the animals will be easily compromised.  As a matter of fact, lymphopaenia accompanied by low globulin level, may lead to immunosuppression. In case of decreased globulin level, diseases characterized by deficiency of immunoglobulin, such as agammaglobulinaemia selective IgM, IgA and IgG deficiencies and transient hypogammaglobulinaemia, may lead to low level globulin (<a href="#Duncan-JR--Prasse-KW--Mahaffey-EA--1994-"><span class="Hyperlink">Duncan et al., 1994</span></a>). Acetamiprid might possess immunosuppressive properties as well as causing inflammatory effects.</p>
		  <p class="Body-Text ParaOverride-1">&nbsp;</p>
			<p class="Body-Text ParaOverride-1">Increased bilirubin in dose dependant manner over the experimental weeks indicated hepatocellular damage which regulated the free bilirubin in plasma. It might be due to reduced feed and water intake which was found in present experiment (<a href="#Ghofrani-HA--Hoeper-MM--Halank-M--Meyer-FJ--Staehler-G--Behr-J--Ewert-R--Weimann-G--Grimminger-F--20"><span class="Hyperlink">Ghofrani et al., 2010</span></a>; <a href="#Ameri-M--Schnaars-H--Sibley-J--Honor-D--2011"><span class="Hyperlink">Ameri et al., 2011</span></a>). </p>
		  <p class="Body-Text ParaOverride-1">&nbsp;</p>
			<p class="Body-Text ParaOverride-1">Increased level of creatinine levels in the acetamiprid treated groups may be due to the possible nephrotoxic effect of acetamiprid. Significant increase in blood creatinine level might be correlated to the renal damage or skeletal muscle necrosis or atrophy of skeletal muscle (<a href="#Pennington-RJ--1971-.-Bi"><span class="Hyperlink">Pennington, 1971</span></a>). It could also be explained by our observation that severe necrotic changes were detected in kidney. This finding was also in agreement with <a href="#Erdem-TL--Ozcan-I--Sermet-B--Balkaya-MC--Ozcan-M--2006"><span class="Hyperlink">Erdem et al. (2006)</span></a>. Significant increase of creatinine level of blood suggested evidence of marked impairment of kidney function (<a href="#Oser-BL--1976"><span class="Hyperlink">Oser, 1976</span></a>).</p>
		  <p class="Body-Text ParaOverride-1">&nbsp;</p>
			<p class="Body-Text ParaOverride-1">Increase in blood urea nitrogen level indicated that acetamiprid has toxic effect on glomerular filtration. Increased blood urea level have been reported in subacute benfuracarb toxicity in wistar rats (<a href="#Bhilegaonkar-DM--Despande-BB--Degloorkar-NM--Moregaonkar-SD--Valdamudi--VP--Rajkumar-SR--1995"><span class="Hyperlink">Bhilegaonkar et al., 1995</span></a>) indicating renal dysfunction in the affected animals.</p>
		  <p class="Body-Text ParaOverride-1">&nbsp;</p>
			<p class="Body-Text ParaOverride-1">Effects of acetamiprid on pancreas and kidney may also be responsible for hypocalcaemia (<a href="#Brar-RS--Sandhu-HS--Singh-A--2002"><span class="Hyperlink">Brar et al., 2002</span></a>). It might be due to renal failure or osteoclastic lesions during chronic acetamiprid toxicity study. An increase in serum calcium concentration was observed in rats treated with 31.80 mg/kg fenvalerate (<a href="#He-J--Chen-JF--Liu-R--Song-L--Chang-HC--Wang-XR--2006-."><span class="Hyperlink">He et al., 2006</span></a>).</p>
		  <p class="Body-Text ParaOverride-1">&nbsp;</p>
			<p class="Body-Text ParaOverride-1">Augmented phosphorus level in plasma may be due to dehydration (<a href="#Sastry-GA--1985"><span class="Hyperlink">Sastry, 1985</span></a>). Oral administration of acetamiprid in distilled water solution might have caused refusal of animals to drink water leading to dehydration. </p>
		  <p class="Body-Text ParaOverride-1">&nbsp;</p>
			<p class="Body-Text ParaOverride-1">Calcium and phosphate metabolism are markedly altered during uraemia and are involved in development of renal secondary hyperparathyroidism in monogastrics (<a href="#Kaneko-JJ--Harvey-JW--Bruss-ML--1999"><span class="Hyperlink">Kaneko et al., 1999</span></a>). It seemed that in course of renal failure there was an analytically imperceptible hyperphosphatemia and hypocalcemia. Hyperphosphatemia observed in rats of group IV might also be due to rhabdomyolysis. The hyperphosphatemia was due to decreased glomerular filtration rate. The hypocalcemia may be a direct physiochemical effect of hyperphosphatemia or, a deficiency of active forms of vitamin D or both. The hypocalcemia stimulates parathyroid hormone release, which enhanced the calcium level in the blood.</p>
		  <p class="Body-Text ParaOverride-1">&nbsp;</p>
			<p class="Body-Text ParaOverride-1">The increase sodium concentration was correlated with the water loss, which was more prominent in high dose group. Due to kidney damage excretion of ammonia through urine is hampered which in turn cause uraemia, leading to anoxic condition in the tissues. Decreased oxygen pressure in the tissue affect ATP production, which is necessary for energy dependent Na-K-ATPase pump in cell membrane. As a result potassium comes out of the cell and sodium went inside the cell along with water leading to hydropic degeneration and subsequently there was rupture of the cells resulting in hypernatremia and hyperkalemia (<a href="#Brar-RS--Sandhu-HS--Singh-A--2002"><span class="Hyperlink">Brar et al., 2002</span></a>).</p>
		  <p class="Body-Text ParaOverride-1">&nbsp;</p>
			<p class="Body-Text ParaOverride-1">There were hyperchloremia in all the acetamiprid treated rats in a dose dependent manner. This might be due to dehydration and compensatory respiratory alkalosis. Most of the chloride in the body comes from table salt (sodium chloride) in the diet. Chloride was absorbed by the intestine during food digestion. Any excess chloride was passed out of the body through the urine. Chloride levels in the blood generally rise and fall along with sodium levels in the blood. The amount of chloride in the blood was indirectly regulated by the hormone aldosterone, which also regulates the amount of sodium in the blood. Elevations in chloride might be associated with diarrhoea, certain kidney diseases and over activity of the parathyroid gland (<a href="#Brar-RS--Sandhu-HS--Singh-A--2002"><span class="Hyperlink">Brar et al., 2002</span></a>).</p>
		  <p class="Body-Text ParaOverride-1">&nbsp;</p>
			<p class="Heading-1--Introduction----">CONCLUSIONS</p>
		  <p class="Heading-1--Introduction----">&nbsp;</p>
			<p class="Body-Text ParaOverride-1">From the present study it can be concluded that chronic acetamiprid intoxication caused lymphocytopenia in SD rats. Exposure of acetamiprid for 13 weeks, even at dose range selected in this experiment, altered the level of AST, ALT, ALP, bilirubin, BUN, Creatinine, phosphorus, Sodium, Potasium and chlorine. </p>
		  <p class="Body-Text ParaOverride-1">&nbsp;</p>
			<p class="Heading-1--Introduction----">ACKNOWLEDGEMENT</p>
		  <p class="Heading-1--Introduction----">&nbsp;</p>
			<p class="Body-Text ParaOverride-1">Authors acknowledge all kind of support from Dean, Faculty of VAS, WBUAFS and also thankfull to HOD, Department of Veterinary Pathology for providing related facilities.</p>
		  <p class="Body-Text ParaOverride-1">&nbsp;</p>
			<p class="Heading-1--Introduction----">Conflict of Interest</p>
		  <p class="Heading-1--Introduction----">&nbsp;</p>
			<p class="Body-Text ParaOverride-1">Authors declare that there is no conflict of interest.</p>
		  <p class="Body-Text ParaOverride-1">&nbsp;</p>
			<p class="Heading-1--Introduction----">Author’s Contribution</p>
		  <p class="Heading-1--Introduction----">&nbsp;</p>
			<p class="Body-Text ParaOverride-1">Samiran Mondal and Sunit Kumar Mukhopadhayay designed, executed and did all assays in the experiment. Sanjit Kumar and Partha Sarathi Mandal collected samples in the experiment. Saktipada Pradhan and Sreerupa Biswas analyzed data of this study. Kamal Purohit prepared and reviewed the manuscript.</p>
		  <p class="Body-Text ParaOverride-1">&nbsp;</p>
			<p class="Heading-1--Introduction----">REFERENCE</p>
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