<!DOCTYPE html>
<html xmlns="http://www.w3.org/1999/xhtml">
	<head>
		<meta charset="utf-8" />
		<title>AAVS_MH20150115140144_Sharma 2</title>
		<link href="http://nexusacademicpublishers.com/uploads/cssfiles/AAVS_MH20150115140144_Sharma 2.css" rel="stylesheet" type="text/css" />
	</head>
	<body id="AAVS_MH20150115140144_Sharma-2" lang="en-GB">
		<div class="Basic-Text-Frame">
			<p class="Type-of-Article">&nbsp;</p>
			<p class="Type-of-Article"><span class="CharOverride-1">Research Article</span></p>
		</div>
		<div class="Basic-Text-Frame">
			<p class="title- ParaOverride-1">&nbsp;</p>
			<p class="title- ParaOverride-1">Multidrug Resistance Pattern of <i>Enterobacter</i> Spp. Isolated from Acute Respiratory Tract Infected Camels (<i>Camelus dromedarius</i>)</p>
		</div>
		<div class="Basic-Text-Frame">
			<p class="Authors ParaOverride-1">&nbsp;</p>
			<p class="Authors ParaOverride-1"><span class="CharOverride-3">Sandeep Kumar Sharma</span><span class="CharOverride-4">1*</span><span class="CharOverride-3">, Rahul Yadav</span><span class="CharOverride-4">2</span><span class="CharOverride-3">, Prerna Nathawat</span><span class="CharOverride-4">3</span></p>
		</div>
		<div class="Basic-Text-Frame">
			<p class="Affiliations ParaOverride-1"><span class="CharOverride-5">1</span>Department of Veterinary Microbiology &amp; Biotechnology, Post Graduate Institute of Veterinary Education and Research (PGIVER)- Jaipur, Rajasthan University of Veterinary and Animal Sciences, Bikaner, India; <span class="CharOverride-5">2</span>Department of Veterinary Microbiology &amp; Biotechnology; <span class="CharOverride-5">3</span>Centre for Studies on Wildlife Management and Health, College of Veterinary &amp; Animal Science- Bikaner, Rajasthan University of Veterinary and Animal Sciences, Bikaner, India. </p>
		</div>
		<div>
			<p class="Abstract ParaOverride-1">&nbsp;</p>
			<p class="Abstract ParaOverride-1"><span class="CharOverride-6">Abstract</span> | The genus <span class="CharOverride-7">Enterobacter</span> is a gram negative commensal coliform member of <span class="CharOverride-7">Enterobacteriaceae</span>. In immunocompromised animals <span class="CharOverride-7">Enterobacter</span> become opportunistic pathogen and severely affects therapeutic management of infections by evading proper effects of antibiotics. Thus the present study was designed to determine resistance pattern of <span class="CharOverride-7">Enterobacter</span><span class="CharOverride-6"> </span>obtained from acute respiratory tract infected camels (<span class="CharOverride-7">Camelus dromedarius</span>). Total 16 <span class="CharOverride-7">Enterobacter </span>spp. isolates were obtained from 46 deep nasal discharge samples of acute respiratory tract infected camels and preliminarily confirmed on the basis of IMViC pattern, hemolysis and sugar fermentation pattern. Confirmed isolates were screened for susceptibility against 25 antibiotics of various groups. All isolates were showed multidrug resistance pattern and 100% isolates were resistant to ampicillin, bacitracin, erythromycin, clindamycin, rifampicin, vancomycin and oxacillin. While all isolates were sensitive to gentamicin and imepenem and in decreasing order isolates were showing variable percentage of sensitivity for cefepime and ciprofloxacin (93.75%), norfloxacin and cefotaxime (87.50%), ceftazidime and co-trimoxazole (81.25%), colistin (68.75%), chloramphenicol (62.50%), kanamycin and trimethoprim (56.25%), tetracycline (31.25%) and cephalothin (25%) isolates were sensitive. </p>
		  <p class="Abstract ParaOverride-1">&nbsp;</p>
			<p class="Abstract ParaOverride-1"><span class="CharOverride-6">Keywords </span>| Multidrug resistance, <span class="CharOverride-7">Enterobacter</span>, Acute respiratory tract infection, Camel</p>
		  <p class="Abstract ParaOverride-1">&nbsp;</p>
		</div>
		<div class="Basic-Text-Frame">
			<p class="Editor----Citation"><span class="CharOverride-9">Editor</span> | Kuldeep Dhama, Indian Veterinary Research Institute, Uttar Pradesh, India.</p>
			<p class="Editor----Citation"><span class="CharOverride-6">Received</span> | December  27, 2014; <span class="CharOverride-6">Revised</span> | January 16, 2015; <span class="CharOverride-6">Accepted</span> | January 20, 2015; <span class="CharOverride-6">Published</span> | January 26, 2015&#9;&#9;</p>
			<p class="Editor----Citation"><span class="CharOverride-6">*Correspondence</span> | Sandeep Kumar Sharma, Rajasthan University of Veterinary and Animals Sciences, Bikaner, India; <span class="CharOverride-6">Email:</span> drsharmask01@hotmail.com</p>
			<p class="Editor----Citation"><span class="CharOverride-6">Citation</span> | Sharma SK, Yadav R, Nathawat P (2015). Multidrug resistance pattern of <span class="CharOverride-20">Enterobacter</span> spp. isolated from acute respiratory tract infected camels (<span class="CharOverride-20">Camelus dromedarius</span>). Adv. Anim. Vet. Sci. 3(2): 128-132.  </p>
			<p class="Editor----Citation"><span class="CharOverride-9">DOI</span> | <a href="http://dx.doi.org/10.14737/journal.aavs/2015/3.2.128.132"><span class="Hyperlink">http://dx.doi.org/10.14737/journal.aavs/2015/3.2.128.132</span></a></p>
			<p class="Editor----Citation"><span class="Editor---Citation CharOverride-6" lang="en-US">ISSN </span><span class="Editor---Citation CharOverride-6" lang="en-US">(</span><span class="Editor---Citation CharOverride-6" lang="en-US">Online</span><span class="Editor---Citation CharOverride-6" lang="en-US">) | 2307-8316; <span class="Editor---Citation CharOverride-6" lang="en-US">ISSN </span><span class="Editor---Citation CharOverride-6" lang="en-US">(Print) </span> | 2309-3331</p>
			<p class="Editor----Citation"><span class="CharOverride-9">Copyright </span>© 2015 Sharma et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</p>
		</div>
		<div class="Basic-Text-Frame">
			<p class="Heading-1--Introduction----">&nbsp;</p>
			<p class="Heading-1--Introduction----">&nbsp;</p>
			<p class="Heading-1--Introduction----">Introduction</p>
		  <p class="Heading-1--Introduction----">&nbsp;</p>
			<p class="Caps-on-First-Para ParaOverride-1"><span class="_idGenDropcap-1">C</span>amel <span class="CharOverride-13">(Camelus dromedarius)</span><span class="CharOverride-14"> is a state animal of Rajasthan and has significant role in economy of poor farmers through various ways such as camel milk, wool, riding and draft. Camel has also important role in agricultural utilities along with especial adaptations for Rajasthan desert but in certain harsh condition like sudden environment changes make it susceptible for opportunistic infections. Pulmonary diseases are among the emerging problems of camels that are causing considerable loss in production and death (</span><a href="#Njage-PMK--Dolci-S--Jans-C--Wangoh-J--Lacroix-C--Meile-L--2012-"><span class="Hyperlink">Njage et al., 2012</span></a><span class="CharOverride-14">; </span><a href="#Al-juboori-AA--Kamat-NK--Sindhu-JI--2013-."><span class="Hyperlink">Al-Juboori et al., 2013</span></a><span class="CharOverride-14">). Genus</span><span class="apple-converted-space CharOverride-14">&#160;</span><span class="CharOverride-13">Enterobacter</span><span class="apple-converted-space CharOverride-14">&#160;</span><span class="CharOverride-14">is more specifically a nosocomial opportunistic pathogen and is sought out to be one of the many key causes for extra intestinal infections next to</span><span class="apple-converted-space CharOverride-14">&#160;</span><span class="CharOverride-13">Escherichia coli </span><span class="CharOverride-14">(</span><a href="#Osterblad-M--Pensala-O--Peterzens-M--Heleniusc-H--Huovinen-P--1999-"><span class="Hyperlink">Osterblad et al., 1999</span></a><span class="CharOverride-14">). In the 1970s, </span><span class="CharOverride-13">Enterobacter</span><span class="CharOverride-14"> was first noted as a common cause of nosocomial infections in immuno-compromised hosts with respiratory, urinary, and gastrointestinal tracts infections (</span><a href="#Wilberger-MS--Anthony-KE--Rose-S--McClain-M--Bermudez-LE--2012-."><span class="Hyperlink">Wilberger et al., 2012</span></a><span class="CharOverride-14">). Thus it was observed that </span><span class="CharOverride-13">Enterobacter</span><span class="CharOverride-14"> commonly associated with respiratory, gastrointestinal and urinary tract infections in addition to wound, bloodstream, and central nervous system infections (</span><a href="#Bordeanu-AD--Krupaci-FA--Kiss-T--Spinu-M--2012-"><span class="Hyperlink">Bordeanu et al., 2012</span></a>).</p>
		  <p class="Caps-on-First-Para ParaOverride-1">&nbsp;</p>
			<p class="Body-Text ParaOverride-1">The physical examination of <span class="CharOverride-7">Enterobacter</span> respiratory tract infections may include high fever, tachycardia, hypoxemia and cyanosis. Infected animal with pulmonary consolidation may present with crackling sounds, dullness to percussion, tubular breath sounds and egophony. Pleural effusion may manifest as dullness to percussion and decreased breath sounds (<a href="#Edward-RR--Ewing-WH--1972-."><span class="Hyperlink">Edward and Ewing, 1972</span></a>; <a href="#Gohary-AHEL--Osman-AO--Safwat-ELS--2012-."><span class="Hyperlink">Gohary et al., 2012</span></a>). Since during the last decade <span class="CharOverride-7">Enterobacter</span> has emerged as an important hospital pathogen responsible for nosocomial respiratory tract infections with exhibiting high resistance to broad-spectrum antibiotics and the emergence of extended-spectrum cephalosporin-resistant strains has been also documented (<a href="#Thiolas-A--Bollet-C--Scola-BL--Raoult-D--Pages-JM--2005-."><span class="Hyperlink">Thiolas et al., 2005</span></a>). In addition to diseases causing, genus<span class="CharOverride-7"> Enterobacter</span><span class="apple-converted-space CharOverride-14">&#160;</span>is also capable to acquire antibiotic resistance in short time with various mechanism such as Beta-lactamase &amp; Extended-Spectrum Beta-lactamase (ESBL) production, multidrug efflux system, low outer membrane permeability, mutations in chromosomal genes and additional acquired resistance genes via plasmids, transposons and phage makes this organism highly resistant (<a href="#Harbottle-H--Thakur-S--Zhao-S--White-DG--2006-."><span class="Hyperlink">Harbottle et al., 2006</span></a>). Though multidrug resistance pattern of <span class="CharOverride-7">Enterobacter</span> among human patients explored well but in animals especially camels it has not studied very much. Thus the present study was carried out to characterize genus<span class="CharOverride-7"> Enterobacter</span><span class="apple-converted-space CharOverride-14">&#160;</span>from respiratory tract infection in camels on the basis of their biochemical properties and to determine multidrug resistance pattern of organism for prevention of further morbidity and mortality of animals because of resistant opportunistic pathogens.</p>
			<p class="Body-Text ParaOverride-1">&nbsp;</p>
		  <p class="Body-Text ParaOverride-1">&nbsp;</p>
			<p class="Heading-1--Introduction----">Material and method</p>
		  <p class="Heading-1--Introduction----">&nbsp;</p>
			<p class="Heading-2--History-in-MM-">Isolation and identification</p>
			<p class="Body-Text ParaOverride-1">A total of 46 samples of deep nasal discharge from acute respiratory tract infected camels were collected aseptically with sterile absorbent swabs soaked in nutrient broth. All samples has been collected from clinical complex of college of veterinary and animal science, Bikaner (Rajasthan) India on the basis of clinical symptoms of acute respiratory tract infection without discrimination of age, sex and breed of camels. The samples were inoculated on  nutrient  agar  plates  and  then  processed  for isolation  and  identification  of <span class="CharOverride-7">Enterobacter </span>spp. (<a href="#Cowan-ST--Steel-KJ--1975-."><span class="Hyperlink">Cowan and Steel 1974</span></a>; <a href="#Quinn-PJ--Carter-ME--Markey-BK--Carter-GR--1994-."><span class="Hyperlink">Quinn et al., 1994</span></a>). Out of the 46 samples 16 suspected isolates were proceeded on the basis of phenotypic and biochemical properties such as cultural characteristics, motility, lactose fermentation, IMViC pattern, H<span class="CharOverride-15">2</span>S production in TSI agar, lysine decarboxylase and urease activity.</p>
		  <p class="Body-Text ParaOverride-1">&nbsp;</p>
			<p class="Heading-2--History-in-MM-">Antibiotic sensitivity test</p>
			<p class="Body-Text ParaOverride-1">To determine the antibiogram of the isolates against various 25 antibiotics (<a href="#Table-1-"><span class="Hyperlink">Table 1</span></a>) the method of <a href="#Bauer-AW--Kirby-WM--Sherris-JC--Turck-M--1966-."><span class="Hyperlink">Bauer et al. (1966)</span></a> was followed. The isolates were inoculated in sterile 5 ml nutrient broth tubes and incubated for 18 hour at 37<span class="CharOverride-5">o</span>C. The opacity was adjusted to 0.5 McFarland opacity standards (<a href="#Quinn-PJ--Carter-ME--Markey-BK--Carter-GR--1994-."><span class="Hyperlink">Quinn et al., 1994</span></a>) and inoculums were well spread over the agar surface with the help of sterilized swab. Plates were allowed to dry for 10 minute at 37<span class="CharOverride-5">o</span>C and then antibiotic discs (Hi Media, Mumbai) were carefully placed on the surface with enough space around each disc for diffusion of the antibiotic. Plates were incubated for 24 hour at 37<span class="CharOverride-5">o</span>C and the diameter of zone of inhibition of growth around each disc was measured in millimeters. After inhibition zone measurement, result interpretation was made with standard chart provided by disc manufacturer (Hi Media, Mumbai).</p>
			<p class="Body-Text ParaOverride-1">&nbsp;</p>
		  <p class="Body-Text ParaOverride-1">&nbsp;</p>
			<p class="Heading-1--Introduction----">Results</p>
		  <p class="Heading-1--Introduction----">&nbsp;</p>
			<p class="Body-Text ParaOverride-1">In the present investigation 16 <span class="CharOverride-7">Enterobacter </span>spp. were isolated from 46 nasal samples from acute respiratory tract infected camels on the basis of their phenotypic and biochemical properties. All the isolates showed pink lactose fermenting, non- metallic sheen, mucoid colonies on respective culture media with  typical IMViC pattern (- - + +) and not produced H<span class="CharOverride-15">2</span>S gas in Triple Sugar Iron (TSI) agar. Typically all isolates were motile, urease positive and negative for lysine decarboxylation. In antibiogram study, all isolates were 100% sensitive to gentamicin and imipenem while completely resistant to ampicillin, bacitracin, erythromycin, clindamycin, rifampicin, vancomycin and oxacillin. All <span class="CharOverride-7">Enterobacters </span>showed multidrug resistance pattern with minimum resistance to fifteen antibiotics. The studied isolates were sensitive with following decreasing percentage such as cefepime &amp; ciprofloxacin (93.75%), norfloxacin &amp; cefotaxime (87.50%), ceftazidime &amp; co-trimoxazole (81.25%) and 56.25% isolates were resistant to tetracycline, 62.50% to cephalothin, 68.75% to ampicillin/sulbactum, 87.50% to nalidixic acid  and 93.75% isolates were resistant to penicillin. All other antibiotics showed variable efficacy as described in <a href="#Table-1-"><span class="Hyperlink">table 1</span></a>.</p>
			<p class="Body-Text ParaOverride-1">&nbsp;</p>
		  <p class="Body-Text ParaOverride-1">&nbsp;</p>
			<p class="Figure--and-Table-Heading ParaOverride-1"><span class="CharOverride-6"><a id="Table-1-"></a>Table 1: </span>Antibiogram of <span class="CharOverride-7">Enterobacter </span>spp. obtained from acute respiratory tract infected camels</p>
			<table width="657" height="635" class="Table-Style-1" id="table-1">
				<colgroup>
					<col class="_idGenTableRowColumn-1" />
					<col class="_idGenTableRowColumn-2" />
					<col class="_idGenTableRowColumn-3" />
					<col class="_idGenTableRowColumn-4" />
					<col class="_idGenTableRowColumn-4" />
					<col class="_idGenTableRowColumn-3" />
				</colgroup>
				<tbody>
					<tr class="_idGenTableRowColumn-5">
						<td rowspan="2">
							<p class="Basic-Paragraph"><span class="CharOverride-16">S. No.</span></p>
						</td>
						<td rowspan="2">
							<p class="Basic-Paragraph"><span class="CharOverride-16">Antibiogram disc</span></p>
						</td>
						<td rowspan="2">
							<p class="Basic-Paragraph"><span class="CharOverride-16">Conc.</span></p>
							<p class="Basic-Paragraph"><span class="CharOverride-16">(mcg/disc)</span></p>
						</td>
						<td colspan="3">
							<p class="Basic-Paragraph"><span class="CharOverride-16">         Percent (Number of isolates)</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-6">
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-16">Sensitive </span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-16">Intermediate</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-16">Resistant</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-7">
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">1</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">Gentamicin (G)</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">120</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">100 (16)</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">-</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">-</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-8">
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">2</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">Imipenem (I)</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">10</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">100 (16)</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">-</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">-</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-7">
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">3</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">Cefepime (Cpm)</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">30</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">93.75 (15)</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">-</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">6.25 (1)</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-8">
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">4</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">Ciprofloxacin (Cf)</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">5</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">93.75 (15)</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">6.25 (1)</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">-</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-7">
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">5</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">Norfloxacin  (Nx)</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">10</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">87.50 (14)</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">6.25 (1)</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">6.25 (1)</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-8">
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">6</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">Cefotaxime (Ce)</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">30</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">87.50 (14)</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">-</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">12.50 (2)</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-7">
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">7</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">Ceftazidime (Ca)</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">30</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">81.25 (13)</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">12.50 (2)</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">6.25 (1)</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-8">
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">8</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">Co-trimoxazole (Co)</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">23.75/1.25</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">81.25 (13)</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">6.25 (1)</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">12.50 (2)</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-7">
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">9</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">Colistin (Cl)</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">10</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">68.75 (11)</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">6.25 (1)</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">25 (4)</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-8">
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">10</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">Chloramphenicol (C)</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">30</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">62.50 (10)</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">-</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">37.50 (6)</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-7">
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">11</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">Kanamycin (K)</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">30</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">56.25 (9)</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">-</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">43.75 (7)</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-8">
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">12</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">Trimethoprim (Tr)</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">5</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">56.25 (9)</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">18.75 (3)</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">25 (4)</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-7">
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">13</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">Tetracycline (T)</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">30</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">31.25 (5)</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">12.50 (2)</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">56.25 (9)</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-8">
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">14</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">Cephalothin (Ch)</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">30</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">25 (4)</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">12.50 (2)</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">62.50 (10)</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-7">
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">15</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">Ampicillin/Sulbactum (A/s)</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">10/10</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">18.75 (3)</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">12.50 (2)</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">68.75 (11)</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-9">
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">16</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">Nalidixic Acid (Na)</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">30</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">12.50 (2)</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">-</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">87.50 (14)</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-10">
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">17</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">Cloxacillin (Cx)</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">10</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">6.25 (1)</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">56.25 (9)</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">37.50 (6)</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-8">
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">18</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">Penicillin (P)</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">10 unit</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">6.25 (1)</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">-</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">93.75 (15)</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-11">
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">19</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">Ampicillin (A)</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">10</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">-</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">-</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">100 (16)</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-12">
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">20</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">Bacitracin (B)</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">10 Units</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">-</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">-</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">100 (16)</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-11">
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">21</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">Erythromycin (E)</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">15</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">-</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">-</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">100 (16)</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-12">
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">22</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">Clindamycin (Cd)</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">2</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">-</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">-</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">100 (16)</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-11">
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">23</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">Rifampicin (R)</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">5</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">-</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">-</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">100 (16)</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-12">
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">24</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">Vancomycin(Va)</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">30</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">-</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">-</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">100 (16)</span></p>
						</td>
					</tr>
					<tr class="_idGenTableRowColumn-11">
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">25</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">Oxacillin(Ox)</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">1</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">-</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">-</span></p>
						</td>
						<td>
							<p class="Basic-Paragraph"><span class="CharOverride-14">100 (16)</span></p>
						</td>
					</tr>
				</tbody>
			</table>
			
		  <p class="Heading-1--Introduction----">&nbsp;</p>
		  <p class="Heading-1--Introduction----">&nbsp;</p>
		  <p class="Heading-1--Introduction----">Discussion</p>
			<p class="Body-Text ParaOverride-1">&#9;</p>
			<p class="Body-Text ParaOverride-1">In the present study, <span class="CharOverride-7">Enterobacter</span> spp. showed typical biochemical and cultural phenotypic characteristic as described in literature (<a href="#Edward-RR--Ewing-WH--1972-."><span class="Hyperlink">Edward and Ewing, 1972</span></a>; <a href="#Cowan-ST--Steel-KJ--1975-."><span class="Hyperlink">Cowan and Steel, 1975</span></a>). Since chromosomal DNA not so rapidly change in comparison to plasmid and most of phenotypic and cultural properties govern by chromosomal DNA so there may possibilities that <span class="CharOverride-7">Enterobacter </span>existing long without any phenotypic variations (<a href="#Holmes-RK--Jobling-MG--1996-."><span class="Hyperlink">Holmes and Jobling, 1996</span></a>). On the basis of several easily performed biochemical tests, <a href="#Zabransky-RJ--Hall-JW--Day-FE--Needham-GM--1969-."><span class="Hyperlink">Zabransky et al. (1969)</span></a> and <a href="#Iversen-C--Waddington-M--Farmer-JJIII--Forsythe-S--2006-."><span class="Hyperlink">Iversen et al. (2006)</span></a> has also characterize <span class="CharOverride-7">Enterobacter spp.</span> obtained from clinical cases. Similar to present study they found biochemical characterization is a reproducible technique for epidemiological surveillance up to genus identification but for precise species differentiation further genotypes (DNA cluster groups based on partial 16SrDNA sequence analysis) characterization is required. </p>
		  <p class="Body-Text ParaOverride-1">&nbsp;</p>
			<p class="Body-Text ParaOverride-1">For antibiotic susceptibility pattern, present study also found similar observation without resistance to cefotaxime, aztreonam, imipenem, gentamicin, nalidixic acid and ciprofloxacin (<a href="#Osterblad-M--Pensala-O--Peterzens-M--Heleniusc-H--Huovinen-P--1999-"><span class="Hyperlink">Osterblad et al., 1999</span></a>) and in the study of <a href="#Magnet-MDMH--Arongozeb-MD--Khan-GM--Ahmed-Z--2013-."><span class="Hyperlink">Magnet et al. (2013)</span></a>, <span class="CharOverride-7">Enterobacter</span> spp. were resistant to most of antibiotics, but were moderately sensitive (50%) to ciprofloxacin, tetracycline and doxycycline. </p>
		  <p class="Body-Text ParaOverride-1">&#9;</p>
			<p class="Body-Text ParaOverride-1">Observations in present study had accordance with the <a href="#Al-juboori-AA--Kamat-NK--Sindhu-JI--2013-."><span class="Hyperlink">Al-Juboori et al. (2013)</span></a>, who revealed that the <span class="CharOverride-7">Enterobacter</span> isolates from clinical and subclinical mastitis from camel milk showed moderate sensitivity to carbenicillin, streptomycin, sulphamethoxazole and gentamicin while less sensitive or even resistive towards ampicillin, colistin, penicillin G and tetracycline. <a href="#Greenup-P--Blazevic-DJ--1971-"><span class="Hyperlink">Greenup and Blazevic, (1971)</span></a> found slight variations that all the 28 strains of <span class="CharOverride-7">Enterobacter</span> were sensitive towards gentamicin, chloramphenicol and nalidixic acid followed by sulfisoxazole, kanamycin, tetracycline, streptomycin and all were resistant to ampicillin. The <span class="CharOverride-7">Enterobacter</span> was resistant to ampicillin (81.3%), chloramphenicol (75.0%), ciproﬂoxacin (6.3%), enroﬂoxacin (18.8%), neomycin (37.5%), norﬂoxacin (25.0%), streptomycin (56.3%) and tetracycline (75.0%) in the study of antimicrobial susceptibility of <span class="CharOverride-7">Enterobacter aerogenes</span> from free-range chickens (<a href="#Ojo-OE--Ogunyinka-OOG--Agbaje-M--Okuboye-JO--Kehinde-OO--Oyekunle-MA--2012-"><span class="Hyperlink">Ojo et al., 2012</span></a>) and the study by <a href="#Nyenje-ME--Tanih-NF--Green-E--Ndip-RN--2012-"><span class="Hyperlink">Nyenje et al. (2012)</span></a> found that <span class="CharOverride-7">Enterobacter cloacae</span> isolates registered 100% susceptibility to ciprofloxacin and various percentages of susceptibility was reported to chloramphenicol and gentamicin (91%) each, nalidixic acid (97%) and streptomycin (94%). In support of present study, these all variable patterns of resistance may prove that <span class="CharOverride-7">Enterobacter</span> not only having variable mechanisms of antibiotic resistance but also has variable multidrug resistance patterns with different source of samples. It may understand that acquired antibiotic resistance may result from the mutation of normal cellular genes, the acquisition of foreign resistance genes, or a combination of these two mechanisms and these mechanisms most commonly governed by mobile genetic elements such as plasmids, transposons and integrons (<a href="#Harbottle-H--Thakur-S--Zhao-S--White-DG--2006-."><span class="Hyperlink">Harbottle et al., 2006</span></a>). The mobile genetic elements are most variable genetic material with organisms, environments and cross transmission conditions thus not only earlier studies but also present observed variable pattern of multidrug resistance among <span class="CharOverride-7">Enterobacter </span>and these genetic component may also explain variation of antibiotic resistance<span class="CharOverride-7"> </span>with different source of samples, geographic regions and host animals (<a href="#Ojo-OE--Ogunyinka-OOG--Agbaje-M--Okuboye-JO--Kehinde-OO--Oyekunle-MA--2012-"><span class="Hyperlink">Ojo et al., 2012</span></a>; <a href="#Al-juboori-AA--Kamat-NK--Sindhu-JI--2013-."><span class="Hyperlink">Al-Juboori et al., 2013</span></a>).</p>
		  <p class="Body-Text ParaOverride-1">&nbsp;</p>
			<p class="Body-Text ParaOverride-1">Although, less information is available regarding <span class="CharOverride-7">Enterobacter</span> antibiotic resistance patterns in veterinary medicine; however, emergence of resistance to beta-lactam agents indicates indiscriminate and excessive use of these antibiotics in food producing animals and for therapeutic management to prevent various infections among animal population (<a href="#Reisbig-MD--Hanson-ND--2004"><span class="Hyperlink">Reisbig and Hanson 2004</span></a>). According to veterinarians practicing in study area, tetracycline, norfloxacin and cephalosporin are more commonly prescribed antibiotics in comparison to gentamicin and yet imipenem is not in veterinary practice thus the usages of these antibiotics positively correlate with increased resistance among <span class="CharOverride-7">Enterobacter</span> strains in this investigation. <a href="#Wilberger-MS--Anthony-KE--Rose-S--McClain-M--Bermudez-LE--2012-."><span class="Hyperlink">Wilberger et al. (2012)</span></a> also found similar positive correlation of increased use of antibiotic and their resistance for enrofloxacin and gentamicin in the USA during study of antibiotic resistance among <span class="CharOverride-7">Enterobacter</span> spp. isolated from infection in animals. </p>
			<p class="Body-Text ParaOverride-1">&#9;</p>
			<p class="Body-Text ParaOverride-1"><a href="#McEwen-SA--Fedorka-Cray-PJ--2002-"><span class="Hyperlink">McEwen and Fedorka-Cray (2002)</span></a> has also concluded that excessive use of antibiotics induces the selection of resistant strains by producing hydrolytic enzymes and decreasing the active drug concentration via the alteration of permeability in outer membranes and enhances persistence and dissemination of antibiotic resistance not only in hospitals but also in food chains and ecosystems. In the presence of above facts, present study may conclude that antibiotic resistance not only govern by various inherited and acquired mechanisms but also by indiscriminate use of antibiotic thus the present study suggest prudent and wise use of antibiotics and further molecular studies to find exact mechanism of antibiotic resistance along with genetic characterization of <span class="CharOverride-7">Enterobacter</span> strains to curb mortality and morbidity due to resistant infections.</p>
		  <p class="Body-Text ParaOverride-1">&nbsp;</p>
			<p class="Heading-1--Introduction----">Acknowledgments</p>
		  <p class="Heading-1--Introduction----">&nbsp;</p>
			<p class="Body-Text ParaOverride-1">We acknowledge the support and facilities provide by Head of department of veterinary microbiology and biotechnology, Dean of college of veterinary and animal science, Bikaner and Dean of Post Graduate Institute of Veterinary Education and Research, Jaipur for this study.</p>
		  <p class="Body-Text ParaOverride-1">&nbsp;</p>
			<p class="Heading-1--Introduction----">References </p>
		  <p class="Heading-1--Introduction----">&nbsp;</p>
			
			  <li class="References ParaOverride-3" lang="en-US"><a id="Al-juboori-AA--Kamat-NK--Sindhu-JI--2013-."></a>Al-juboori AA, Kamat NK, Sindhu JI (2013).Prevalence of some mastitis causes in dromedary camels in Abu Dhabi, United Arab Emirates. Iraqi J. Vet. Sci.<span class="CharOverride-7"> </span>27(1):<span class="CharOverride-7"> </span>9-13.</li>
				<li class="References ParaOverride-3" lang="en-US"><a id="Bauer-AW--Kirby-WM--Sherris-JC--Turck-M--1966-."></a>Bauer AW, Kirby WM, Sherris JC, Turck M (1966). Antibiotic susceptibility testing by a standardized single disc method. Am. J. Clin. Pathol. 45(4): 493-496. </li>
				<li class="References ParaOverride-3" lang="en-US"><a id="Bordeanu-AD--Krupaci-FA--Kiss-T--Spinu-M--2012-"></a>Bordeanu AD, Krupaci FA, Kiss T, Spinu M (2012). Study of seasonal dynamics in respiratory microbial flora in extensively raised goats. Vet. Med.<span class="CharOverride-7"> </span>(8)4: 38-45.</li>
				<li class="References ParaOverride-3" lang="en-US"><a id="Cowan-ST--Steel-KJ--1975-."></a>Cowan ST, Steel KJ (1975). In: Cowan and Steel’s Mannual for the identification of medical bacteria. Cambridge University Press, Cambridge.</li>
				<li class="References ParaOverride-3" lang="en-US"><a id="Edward-RR--Ewing-WH--1972-."></a>Edward RR, Ewing WH (1972). Identification of Enterobacteriaceae. 3<span class="CharOverride-5">rd</span> Ed.  Mennepolis, Gurgess Publ. Co.</li>
				<li class="References ParaOverride-3" lang="en-US"><a id="Gohary-AHEL--Osman-AO--Safwat-ELS--2012-."></a>Gohary AHEL, Osman AO, Safwat ELS (2012). Some bacteriological studies on <span class="CharOverride-7">Enterobacter cloacae</span> And Other <span class="CharOverride-7">Enterobacteria</span> In genital tract of small ruminant. J. Egypt. Vet. Med. Assoc.<span class="Emphasis CharOverride-18"> 72(4): 651-663.</span></li>
				<li class="References ParaOverride-3" lang="en-US"><a id="Greenup-P--Blazevic-DJ--1971-"></a>Greenup P, Blazevic DJ (1971). Antibiotic Susceptibilities of <span class="CharOverride-7">Serratia marcescens</span> and <span class="CharOverride-7">Enterobacter liquefaciens</span>. Appl.<span class="CharOverride-7"> Microbiol.</span> 22(3): 309-314.</li>
				<li class="References ParaOverride-3" lang="en-US"><a id="Harbottle-H--Thakur-S--Zhao-S--White-DG--2006-."></a>Harbottle H, Thakur S, Zhao S, White DG (2006). Genetics of antimicrobial resistance. Anim. Biotechnol. 17(2): 111-124. <a href="http://dx.doi.org/10.1080/10495390600957092"><span class="Hyperlink">http://dx.doi.org/10.1080/10495390600957092</span></a></li>
				<li class="References ParaOverride-3" lang="en-US"><a id="Holmes-RK--Jobling-MG--1996-."></a>Holmes RK, Jobling MG (1996). Genetics. In: Medical Microbiology, 4<span class="CharOverride-5">th</span> ed. Galveston (TX): University of Texas Medical Branch at Galveston.</li>
				<li class="References ParaOverride-3" lang="en-US"><a id="Iversen-C--Waddington-M--Farmer-JJIII--Forsythe-S--2006-."></a>Iversen C, Waddington M, Farmer JJIII, Forsythe S (2006). The biochemical differentiation of <span class="CharOverride-7">Enterobacter sakazakii</span> genotypes. BMC Microbiol. 6: 94. <a href="http://dx.doi.org/10.1186/1471-2180-6-94"><span class="Hyperlink">http://dx.doi.org/10.1186/1471-2180-6-94</span></a></li>
				<li class="References ParaOverride-3" lang="en-US"><a id="Magnet-MDMH--Arongozeb-MD--Khan-GM--Ahmed-Z--2013-."></a>Magnet MDMH, Arongozeb MD, Khan GM, Ahmed Z (2013). Isolation and identification of different bacteria from different types of burn wound infections and study their antimicrobial sensitivity pattern<span class="CharOverride-7">. </span>Int J. Res. Appl., Nat. Soc. Sci.1(3): 125-132.</li>
				<li class="References ParaOverride-3" lang="en-US"><a id="McEwen-SA--Fedorka-Cray-PJ--2002-"></a>McEwen SA, Fedorka-Cray PJ (2002). Antimicrobial use and resistance in animals. CID. 34(3): S93–S106. <a href="http://dx.doi.org/10.1086/340246"><span class="Hyperlink">http://dx.doi.org/10.1086/340246</span></a></li>
				<li class="References ParaOverride-3" lang="en-US"><a id="Njage-PMK--Dolci-S--Jans-C--Wangoh-J--Lacroix-C--Meile-L--2012-"></a>Njage PMK, Dolci S, Jans C, Wangoh J, Lacroix C, Meile L (2012). Ampicillin resistance and extended spectrum <span class="CharOverride-19">β</span>-lactamases in Enterobacteriaceae isolated from raw and spontaneously fermented camel milk.  African J. Microbiol. Res. 6(7): 1446-1452.</li>
				<li class="References ParaOverride-3" lang="en-US"><a id="Nyenje-ME--Tanih-NF--Green-E--Ndip-RN--2012-"></a>Nyenje ME, Tanih NF, Green E, Ndip RN (2012). Current Status of Antibiogram of <span class="CharOverride-7">Listeria ivanovii</span> and <span class="CharOverride-7">Enterobacter cloacae</span> isolated from ready-to-eat foods in Alice, South Africa. Int. J. Environ. Res. Pub. Health<span class="CharOverride-7">.</span> 9(9): 3101-3114. <a href="http://dx.doi.org/10.3390/ijerph9093101"><span class="Hyperlink">http://dx.doi.org/10.3390/ijerph9093101</span></a></li>
				<li class="References ParaOverride-3" lang="en-US"><a id="Ojo-OE--Ogunyinka-OOG--Agbaje-M--Okuboye-JO--Kehinde-OO--Oyekunle-MA--2012-"></a>Ojo OE, Ogunyinka OOG, Agbaje M, Okuboye JO, Kehinde OO, Oyekunle MA (2012). Antibiogram of <span class="CharOverride-7">Enterobacteriaceae</span> isolated from free-range chickens isolated from free-range chickens in Abeokuta, Nigeria. Vet. Arhiv. 82(6): 577-589.</li>
				<li class="References ParaOverride-3" lang="en-US"><a id="Osterblad-M--Pensala-O--Peterzens-M--Heleniusc-H--Huovinen-P--1999-"></a>Osterblad M, Pensala O, Peterzens M, Heleniusc H, Huovinen P (1999). Antimicrobial susceptibility of <span class="CharOverride-7">enterobacteriaceae</span> isolated from vegetables. J. Antimicrob. Chemo. 43(4): 503-509. <a href="http://dx.doi.org/10.1093/jac/43.4.503"><span class="Hyperlink">http://dx.doi.org/10.1093/jac/43.4.503</span></a></li>
				<li class="References ParaOverride-3" lang="en-US"><a id="Quinn-PJ--Carter-ME--Markey-BK--Carter-GR--1994-."></a>Quinn PJ, Carter ME, Markey BK, Carter GR (1994). Clinical Veterinary Microbiology. Wolfe Publishing, Mosby-Year Book Europe Ltd. Lynton House. Pp. 7-12.</li>
				<li class="References ParaOverride-3" lang="en-US"><a id="Reisbig-MD--Hanson-ND--2004"></a>Reisbig MD, Hanson ND (2004). Promoter sequences necessary for high-level expression of the plasmid associated ampC b-lactamase gene bla MIR-1. Antimicrob. Agents Chemother. 48(11): 4177-4182. <a href="http://dx.doi.org/10.1128/AAC.48.11.4177-4182.2004"><span class="Hyperlink">http://dx.doi.org/10.1128/AAC.48.11.4177-4182.2004</span></a></li>
				<li class="References ParaOverride-3" lang="en-US"><a id="Thiolas-A--Bollet-C--Scola-BL--Raoult-D--Pages-JM--2005-."></a>Thiolas A, Bollet C, Scola BL, Raoult D, Pages JM (2005). Successive Emergence of <span class="CharOverride-7">Enterobacter aerogenes</span> Strains Resistant to Imipenem and Colistin in a Patient. Antimicrob. Agents Chemother. 49(4): 1354-1358. <a href="http://dx.doi.org/10.1128/AAC.49.4.1354-1358.2005"><span class="Hyperlink">http://dx.doi.org/10.1128/AAC.49.4.1354-1358.2005</span></a></li>
		  <li class="References ParaOverride-3" lang="en-US"><a id="Wilberger-MS--Anthony-KE--Rose-S--McClain-M--Bermudez-LE--2012-."></a>Wilberger MS, Anthony KE, Rose S, McClain M, Bermudez LE (2012). Beta-Lactam Antibiotic Resistance among Enterobacter spp. Isolated from Infection in Animals. Adv. Microbiol. 2: 129-137. <a href="http://dx.doi.org/10.4236/aim.2012.22018"><span class="Hyperlink">http://dx.doi.org/10.4236/aim.2012.22018</span></a></li>
				<li class="References ParaOverride-3" lang="en-US"><a id="Zabransky-RJ--Hall-JW--Day-FE--Needham-GM--1969-."></a>Zabransky RJ, Hall JW, Day FE, Needham GM (1969). <span class="CharOverride-7">Klebsiella, Enterobacter</span>, and <span class="CharOverride-7">Serratia</span>: Biochemical Differentiation and Susceptibility to Ampicillin and Three Cephalosporin Derivatives. App. Microbiol. 18(2): 198-203.</li>
                <p>&nbsp;</p>
                <p>&nbsp;</p>
                <p>&nbsp;</p>
			
		</div>
	</body>
</html>
